Knowledge Foundation

Supporting clinical guidelines for opioid conversion to methadone and tapering to prevent withdrawal in critically ill children using physiology based pharmacokinetic modeling and simulation

Long-term opioid use is common in critically ill children and can cause withdrawal symptoms at discontinuation. To avoid withdrawal, short-acting opioids are usually converted into a long-acting drug, such as methadone, which is then carefully tapered. However, the exact conversi...

KENOS - The Full Spectrum Operating Environment (Beta Live) with KAI Nexus Multiple Intelligence Orchestration Loop

This public-safe technical disclosure introduces KAI Nexus, the multi-intelligence orchestration layer within KAI (Kohenoor Artificial Intelligence) and the wider KENOS ecosystem. KAI Nexus is designed to coordinate heterogeneous AI models for advanced advisory workflows. At a hi...

“A beautiful chaos¨: a qualitative study on exploring the role of international communities of practice in knowledge translation for sexual and reproductive health and rights

Persistent knowledge-to-action gaps in sexual and reproductive health and rights (SRHR) limit the translation of evidence into policy and practice. Knowledge platform Share-Net International (SNI) uses Communities of Practice (CoPs) to support knowledge exchange, yet little is kn...

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides

Approximately 30% of tumors contain an activating mutation in the oncogene KRAS, leading to increased cell proliferation that often promotes non-small cell lung cancers, colorectal adenocarcinomas, pancreatic ductal adenocarcinomas (PDAC), and other cancers. Among the most common...

Staggered school start times for reducing peak travel demand: A case study of implementation processes and stakeholder impacts

In Sweden, peak-hour travel demand is ranked as the most important operational cost driver for public transport, linked to school and work hours. Achieving a more balanced demand throughout the day is therefore crucial for resource efficiency and promoting environmentally friendl...