Kitano Hospital

Carbonic anhydrase VIII regulates IP3R1-dependent Ca 2+ signaling to coordinate insulin secretion and hepatic glucose production

Intracellular Ca 2+ signaling is essential for glucose-induced insulin secretion (GIIS) and hepatic glucose production (HGP), yet how Ca 2+ dynamics are coordinated across organs remains unclear. Carbonic anhydrase VIII (CA8), an endogenous inhibitor of inositol 1,4,5-trisphospha...

Effects of installing a volatile organic compound-removal filter in a clinical embryology laboratory on embryo development

Objective: Improving embryo quality is essential for increasing pregnancy and live birth rates in assisted reproductive technology (ART). The culture environment strongly influences embryo quality, and air quality is one of its key components. Volatile organic compounds (VOCs) pr...

Efficacy of Tympanic Membrane Regeneration Therapy for Secondary Cholesteatoma With Tympanic Membrane Perforation

OBJECTIVE: To investigate the effectiveness of tympanic membrane (TM) regeneration therapy (TMRT) for secondary cholesteatoma (SC) with TM perforation (TMP). STUDY DESIGN: Retrospective case review. SETTING: General hospitals. PATIENTS: The study included 38 patients (41 ears) wi...

Transplant outcomes after intensive chemotherapy or venetoclax plus azacitidine in acute myeloid leukemia: a multicenter retrospective study in Japan

The present retrospective multicenter study in Japan evaluated the role of venetoclax plus azacitidine (V/A) before first allogeneic hematopoietic stem cell transplantation (SCT) in 144 transplant-eligible acute myeloid leukemia (AML). Thirty-seven patients received V/A prior to...

Insulin Dosing Is Associated With Cardiac Sympathetic Predominance Independent of Glycemic Profiles in Type 1 Diabetes Under Free-Living Conditions

While insulin activates the sympathetic nervous system in experimental settings, whether therapeutic insulin administration is associated with cardiac sympathetic predominance under free-living conditions remains unclear. This prospective observational study investigated the asso...

Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk

Moderate-to-vigorous physical activity (MVPA) lowers the risk of type 2 diabetes (T2D). Identifying protein modules that mediate this association may help dissect these biological underpinnings, but they remain incompletely characterized. We studied 28,842 diabetes-free UK Bioban...

Smartphone-measured heart rate variability and quality of life in patients with gynecological cancer: a multicenter prospective study

In this study, we aimed to investigate the association between heart rate variability (HRV) and quality of life (QoL) in patients with gynecological cancer and examine whether continuous HRV monitoring may help identify QoL deterioration. This multicenter, prospective, observatio...