King's College School

Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol

Objectives Diabfrail-Latam is a project funded by the Horizon 2020 program of the European Commission (EC) and the Global Alliance for Chronic Diseases (GACD). The main objective of this protocol is to describe the clinical validation of a multimodal intervention aimed at older p...

ACTIVATE: A protocol for a randomised controlled evaluation of Thumos: A cognitive-behavioural intervention for medical students

Background Medical students experience high rates of burnout and mental health distress, with approximately half reporting burnout, one-third experiencing depression, and one-tenth having suicidal thoughts. These issues are exacerbated during clinical placements and contribute to...

Assessing the role of plan complexity and target geometry through multi‐institutional gel based end‐to‐end QA in multi‐focal single isocenter stereotactic radiosurgery

BACKGROUND: Single-isocenter stereotactic radiosurgery enables efficient treatment of multiple brain metastases (SI-MBM SRS), but demands high geometric accuracy. Plan complexity metrics are increasingly used as indicators for quality assurance (QA) performance, however their app...

Turning points in climate change adaptation: Storytelling and co-producing visions and pathways for creating well-adapted places

Clear adaptation outcomes are essential for driving climate action and assessing progress. However, developing a shared vision of desirable adaptation outcomes and the steps to achieve them requires a shared understanding of what constitutes a well-adapted place and what resource...

Centring the voices of birth mothers who faced infant removal through the co-production of the MUMS@RISC artwork: an arts-based evaluation of trauma-informed research collaboration and participation

Abstract Background In the UK, newborn babies are a growing group of children entering the care system due to safeguarding concerns. Their mothers often experienced a life course of adversity and trauma, resulting in fractured trust in public services and health and social care p...

Advancing human sensorimotor research through modular robotics: the case of the HRX-1

The HRX-1 is a single-degree-of-freedom, direct-drive, modular and reconfigurable robotic device designed for investigating human sensorimotor control. By examining its use, this case study highlights the opportunities offered by modular, portable and user-centred open-source des...

Developing management theory from sports: insights from association football

Purpose This paper explores how research on association football (also referred to as “soccer” in the USA) published in leading management and strategy journals contributes to the advancement of general management theory. By leveraging football as a viable field of scholarly inve...

Capital taxation, income shifting and retained earnings: evidence from dividend tax reforms

Abstract In this paper, we analyse the effects of dividend tax reforms on tax revenues, income shifting and earnings retention. We examine two significant policy changes in Israel during the 2010s. Using administrative tax records, we study a permanent increase of 5 percentage po...

User experience and reported challenges with stoma care products: an online survey of people with a stoma

Abstract Background Quality of life (QoL) in people living with a stoma has been assessed by several patient-reported experience measures, but few studies have examined the quality of user experience (UX) associated with stoma care and management products specifically. This explo...

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

PURPOSE: Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluatin...

Theoretical insights into the electronic structure and NBO features driving nonlinear optical enhancement in the donor–π–acceptor system of OPPh3py

Abstract Organic materials capable of intramolecular charge transfer (ICT) are of considerable interest for photonic, biophysics and medicine applications because of their strong nonlinear optical (NLO) responses and favourable electro-optic properties. In this work, diphenyl-[2-...

Leveraging Foundation Models for the Characterisation of Small RNA Properties

ABSTRACT Small interfering RNAs (siRNAs) provide a promising therapeutic approach capable of selectively silencing disease-associated genes; however, achieving high efficacy and specificity while minimising off-target effects remains a significant challenge. Endogenous small RNAs...

PPI and researcher perspectives of islet transplantation therapy for type 1 diabetes

AIMS: Islet transplantation offers the potential of a cure for type 1 diabetes (T1D), but the limited availability of human donor islets means that this therapy is currently only available to a small group of people with T1D who have intractable hypoglycaemia. The shortage of don...

Disentangling the drivers of heterogeneity in SARS-CoV-2 transmission from data on viral load and daily contact rates

Abstract SARS-CoV-2 transmission is highly overdispersed, with a minority of individuals responsible for the majority of transmission, though the drivers of this heterogeneity are unclear. Here, we assess the contribution of variation in viral load and daily contact rates to this...

Beyond Surface Catalysis: Dynamic Cation‐Regulated Interfacial Water Gating for Aqueous Polysulfide Electrochemistry

ABSTRACT Aqueous sulfur electrochemistry holds great promise for high‐energy density storage but is currently constrained by sluggish redox kinetics and severe polarization. Despite extensive efforts in catalyst design to enhance polysulfide adsorption, kinetic improvements have...

Scalar position characteristics and translocation rates of different lateral wall electrodes within the cochlear basal turn: a cone beam computed tomography study

PURPOSE: This retrospective study systematically compared scalar position characteristics and translocation (STL) rates within the cochlear basal turn (CBT) across three different lateral wall (LW) electrodes. METHODS: The study included 148 morphologically normal cochleae implan...

Anticoagulation and Antiplatelet Therapy in Chronic Subdural Hematoma: A Multicenter Evaluation

BACKGROUND AND OBJECTIVES: Chronic subdural hematomas (cSDH) are among the most common neurosurgical pathologies. Older adults also often have comorbidities treated with anticoagulant and antiplatelet (ACAP) medications. Managing clinicians frequently must weigh the benefits and...

Fit to fly? Evaluating airline guidance for passengers with orthopaedic immobilisation

INTRODUCTION: Air travel with cast immobilisation increases the risk of compartment syndrome and venous thromboembolism due to cabin pressure-related tissue swelling and venous stasis. Despite these concerns, guidance on flying with casts is often vague and inconsistent. This stu...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...