King's College Hospital

Sex-dependent DNA methylation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated with ALS differ between the sexes, which would point to sex-sp...

Intravascular Lithotripsy in Left Main Stem Percutaneous Coronary Intervention

ABSTRACT Background IVL is increasingly used for coronary calcium modification; however, prospective data for its use in LMS lesions are lacking. Aims To evaluate the feasibility, safety, and mechanical efficacy of intravascular lithotripsy (IVL) for calcium modification in calci...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Navigated Intraoperative Ultrasound in Functionally Eloquent Tumour Resection: A Descriptive Single-Centre Series Within the Modern Multimodal Neuro-Oncology Surgery Workflow

Background/Objectives: Navigated intraoperative ultrasound (N-ioUS) compensates for brain shift, but its place within a multimodal workflow alongside neuronavigation, 5-aminolevulinic acid (5-ALA) fluorescence and neurophysiological monitoring is not well defined. We describe fun...

The Maxillofacial Academic Practice (MAP) study phase 1: oral and maxillofacial surgical trainee research engagement.

The British Association of Oral and Maxillofacial Surgeons (BAOMS) funded Maxillofacial Academic Practice (MAP) study aims to define the current state of research and academic training within UK Oral and Maxillofacial Surgery (OMFS). Phase One of the study, the OMFS Trainee Resea...

Hypokinesia and bradykinesia in Parkinson’s disease are consistent with reduced motor vigour, not an impaired capacity to generate and transmit neural drive to muscle

Abstract Hypokinesia and bradykinesia in Parkinson’s disease have been attributed to reduced motor vigour, an account that assumes the neural drive to muscle is intact but inappropriately scaled; an alternative is that generation of the drive is itself impaired. We recorded high-...

The Power of Data: Assessing Primary Care Performance Using Routinely Collected Emergency Department Data

This paper develops and validates an approach to assess the impact of individual primary care practices (PCPs) on demand for emergency department (ED) services. Using operational data from two geographically adjacent EDs in England, we focus on attendances for ambulatory care-sen...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Extensive and differential platinum chemotherapy mutagenesis in livers of children

Childhood cancer survivors often experience late adverse effects that may be linked to chemotherapy mutagenesis. We studied chemotherapy mutagenesis in normal pediatric tissues using duplex sequencing (NanoSeq) to enable the detection of mutations from single DNA molecules. We fo...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

45 Predicting sites of tumour progression in the invasive margin of glioblastomas (PRaM-GBM Study): a multicentre imaging study

Abstract Introduction Despite advances in surgery and radiotherapy, glioblastoma patients often experience progression within a year, adjacent to the resection cavity. Conventional imaging techniques are not sensitive enough to detect invasive tumour, leaving occult tumour undete...

Dosimetry and immunohistochemistry study to establish radiolabelled prostate-specific membrane antigen (PSMA) as a potential theranostic target in high-grade glioma treatment

Abstract Prostate-specific membrane antigen (PSMA) is upregulated in high-grade glioma (HGG). This study aimed, firstly, to establish dosimetry for the radionuclide [68Ga]-PSMA-11 in HGG patients; secondly, to determine theoretical tumour doses for [177Lu]-PSMA, a potential thera...

Nut consumption and the risk of hypertension: a systematic review and dose response meta-analysis of prospective studies

Abstract Previous studies have suggested that a high intake of nuts may reduce the risk of hypertension, however, the available data have been limited. Several additional studies have recently been published on the topic. We therefore conducted a systematic review and meta-analys...

Balancing cancer innovation with sustainable care

<i>Investment in innovative drugs must not come at the expense of wider cancer services</i>