King's College Hospital

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

45 Predicting sites of tumour progression in the invasive margin of glioblastomas (PRaM-GBM Study): a multicentre imaging study

Abstract Introduction Despite advances in surgery and radiotherapy, glioblastoma patients often experience progression within a year, adjacent to the resection cavity. Conventional imaging techniques are not sensitive enough to detect invasive tumour, leaving occult tumour undete...

Dosimetry and immunohistochemistry study to establish radiolabelled prostate-specific membrane antigen (PSMA) as a potential theranostic target in high-grade glioma treatment

Abstract Prostate-specific membrane antigen (PSMA) is upregulated in high-grade glioma (HGG). This study aimed, firstly, to establish dosimetry for the radionuclide [68Ga]-PSMA-11 in HGG patients; secondly, to determine theoretical tumour doses for [177Lu]-PSMA, a potential thera...

Nut consumption and the risk of hypertension: a systematic review and dose response meta-analysis of prospective studies

Abstract Previous studies have suggested that a high intake of nuts may reduce the risk of hypertension, however, the available data have been limited. Several additional studies have recently been published on the topic. We therefore conducted a systematic review and meta-analys...

Balancing cancer innovation with sustainable care

<i>Investment in innovative drugs must not come at the expense of wider cancer services</i>