King Saud Medical City

Depression and Anxiety Among Adolescents with Cancer: A Saudi Cross-Sectional Study

Background/Objectives: Adolescents undergoing treatment for cancer face both physical and psychological challenges, including depression and anxiety, yet local prevalence data remain limited in Saudi Arabia. The primary objective was to determine the prevalence of depressive and...

In vitro and in vivo functional roles of three region 1 promoters in Escherichia coli K1 capsule gene cluster

Capsular polysaccharides are key virulence determinants in extraintestinal pathogenic Escherichia coli , protecting bacteria from host immune defences while modulating interactions with host tissues. In group 2 capsule gene clusters, transcription of region 1 genes required for c...

Lash Ptosis and Entropion after Congenital Ptosis Surgery: Mechanisms and Treatment

PURPOSE: This perspective proposes a clinically useful framework for understanding upper eyelid lash ptosis and entropion after congenital ptosis surgery, linking potential mechanisms to prevention and management. METHODS: A focused literature review was performed. RESULTS: Posto...

CT-based distribution of paranasal sinus involvement in sinusitis: A retrospective single-centre study

Background Sinusitis is among the most common inflammatory conditions of the paranasal sinuses, and computed tomography (CT) is the reference modality for demonstrating sinus involvement. The maxillary sinus is generally reported as the most frequently affected, but local data fr...

Dentists’ perceptions and system-level barriers to antimicrobial stewardship in dental care in Karachi, Pakistan: a qualitative study

Abstract Background Antimicrobial resistance (AMR) is a major global health threat, and dental practice is an important but frequently overlooked contributor to inappropriate antibiotic use. In Pakistan, antimicrobial stewardship (AMS) in dentistry remains nascent, and dentists’...

The impact of hospital ethical climate on turnover intention among nurses working in intensive care, oncology, and emergency department units: a cross sectional study

Hospital ethical climate is a key determinant of the quality of nursing care and plays a critical role in shaping nurses’ professional experiences. A positive ethical environment has been associated with improved job satisfaction and reduced nurse turnover intention. This study a...

Norepinephrine Versus Vasopressin as First-Line Vasopressor Therapy in Septic Shock: Implications for Patients Presenting to the Emergency Department

Background: Septic shock requires rapid restoration of perfusion with infection treatment. Norepinephrine is the recommended initial vasopressor, while vasopressin offers an alternative mechanism of vascular support. This review examines comparative clinical outcomes and their re...

Longitudinal Regional Trends in Healthcare Capacity and Recorded Service Utilization in the Saudi Ministry of Health, 2016–2024

Background/Objectives: Regional monitoring is needed to determine how Ministry of Health (MoH) healthcare supply and recorded service utilization changed during Saudi Arabia’s health-sector transformation. This descriptive study examines selected indicators relevant to Sustainabl...

Stroke incidence and phenotype in Saudi patients with sickle cell disease: A longitudinal cohort study

Summary Stroke is a major cause of morbidity in sickle cell disease (SCD); however, contemporary longitudinal data from Saudi cohorts remain limited. We examined stroke incidence, phenotype and laboratory correlates in 195 patients with homozygous sickle cell anaemia (HbSS) or si...

Determinants of incomplete nuclear medicine examinations following radiopharmaceutical administration: A mixed-methods clinical audit at a tertiary hospital in Saudi Arabia

Objective To identify the prevalence and clinical determinants of incomplete nuclear medicine (NM) examinations following radiopharmaceutical administration, and to assess their impact on nuclear medicine practice efficiency and radiopharmaceutical utilization at a tertiary hospi...

Descemet Membrane Detachment Presenting as Graft Edema After Arcuate Keratotomy in an Eye with Previous Penetrating Keratoplasty—A Case Report

Introduction and Clinical Significance: Descemet membrane detachment (DMD) is an uncommon but potentially vision-threatening complication of anterior segment surgery. Although immune-mediated graft rejection is a recognized cause of postoperative graft edema following arcuate ker...

Association of organisational culture and internal participation with job satisfaction among physiotherapists: a cross-sectional study

Abstract This cross-sectional study aimed to examine the independent and combined relationships of organisational culture and internal participation with job satisfaction of physiotherapists. Data was collected through an online survey of licenced physiotherapists in Saudi Arabia...

Nurses’ Perceptions and Behaviors Regarding Climate Change and Health: A Correlational Study Aligned With Saudi Vision 2030

ABSTRACT Climate change is an escalating threat to population health, placing increasing pressure on healthcare systems. Nurses play a pivotal role in delivering climate‐resilient healthcare; however, evidence regarding their perceptions and climate‐related health behaviors in Sa...

Willingness to Share Smartwatch-Generated Health Data Among a Sample of Adults in Riyadh, Saudi Arabia

Background/Objectives: Wearable devices, such as smartwatches, represent an emerging digital health tool that can enhance patient engagement, support patient-provider communication, and enable more personalized, patient-centered care. Understanding public willingness to share hea...

Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals

Background: COVID-19 vaccines have proven effective in reducing severe disease and mortality from SARS CoV-2 infection. The underlying molecular mechanisms and alterations in the human serum metabolome influencing the effectiveness and development of immunity remain unclear. Meth...

Medication reconciliation documentation and documented discrepancies in a tertiary Saudi hospital: a retrospective observational study

Abstract Introduction Medication reconciliation is a key patient-safety process during transitions of care, but its routine documentation and associated medication-list findings are not well described in Saudi tertiary hospital practice. This study aimed to characterize medicatio...

Perceptions of generative AI in medical education: a qualitative descriptive SWOT analysis with a descriptive quantitative component among undergraduate medical students

Generative artificial intelligence (GAI) is rapidly transforming education, reshaping how students access knowledge and engage with learning. In medical education specifically, GAI tools present both significant opportunities and notable challenges, raising questions about their...

Experiences of Saudi Adults Living with Heart Failure: A Reflexive Thematic Analysis of Health-Related Quality of Life

Background: Heart failure is a chronic and progressive condition that substantially affects patients’ physical, emotional, social, and spiritual well-being. Although the clinical burden of heart failure is well documented, limited qualitative evidence exists regarding how Saudi a...

Presentation: Polyvinyl Chloride-Related Insulin Adsorption in Critical Care

This presentation summarizes the key findings of the published narrative review: Elgazzar SH, Ibrahim RK, Ayoub YM, et al. Polyvinyl chloride-related insulin adsorption in critical care: a narrative review with implications for patient safety and green hospital reform. Frontiers...