King Hussein Cancer Center

Globalising the access to advanced molecular diagnostics of CNS tumors: Experience of the Molecular Neuro-Pathology (MNP) Outreach Consortium

Central nervous system (CNS) tumors pose a major global health challenge, particularly in low- and middle-income countries (LMICs), where outcomes remain disproportionately poor. The global CONCORD-3 study (Lancet Oncology) highlighted stark disparities in five-year survival (201...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Integrated multiomic diagnostics in central nervous system tumors from clinical readiness to practical prioritization

Central nervous system (CNS) tumors represent a biologically heterogeneous group of neoplasms in which accurate classification is essential for prognosis, therapeutic planning, and clinical trial eligibility. Contemporary diagnosis increasingly incorporates molecular findings alo...

Bacterial profile and antibiotic susceptibility of bloodstream infections among infants, children, and adolescents undergoing treatment for acute leukemia

Introduction Pediatric patients with acute leukemia are at risk of bacteremia due to disease and treatment-related toxicities. Limited data exists on pathogen distribution across different pediatric age groups. This study aims to investigate the distribution of bacterial pathogen...

Quality Components for Pediatric Cancer Communication in Global Settings

BACKGROUND AND OBJECTIVES In pediatric cancer care, high-quality communication reduces parental anxiety, increases trust, enables decision-making, and fosters hope. This study sought to develop globally applicable quality components for patient-centered pediatric cancer communica...

Use and perceived utility of ChatGPT among participating medical students in selected MENA settings: a cross-sectional survey

ChatGPT is a language model, developed by OpenAI, that uses contextual understanding that allows it to generate relevant responses based on current input and previous context. ChatGPT has infiltrated many fields, including medicine. As the demand for medical education tools is in...

Gut microbiome profiles in locally advanced rectal cancer after total neoadjuvant therapy: comparisons with healthy controls and associations with survival

The gut microbiome plays a key role in colorectal carcinogenesis, but its composition and prognostic relevance in locally advanced rectal cancer (LARC) remain underexplored. This study aimed to assess microbial diversity, identify distinct bacterial signatures in LARC patients co...

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly in...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...

Molecular characterization of mismatch repair deficient tumors in young Jordanian patients

<title>Abstract</title> In Jordan, approximately 19% of colorectal carcinomas (CRCs) in patients younger than 45 years show mismatch repair deficiency (MMRD) by immunohistochemistry (IHC). MMRD in pediatric high-grade gliomas (HGG) and CRC in Jordan appears substantially more fre...

Anaphylactic reaction to the second dose of dacarbazine following initial exposure in patient with hodgkin lymphoma

IntroductionDacarbazine is generally well-tolerated, apart from its hematologic toxicities; however, rare and life-threatening anaphylactic reactions have been reported. We aimed to describe a rare case of anaphylactic reaction to dacarbazine following a previously tolerated firs...

Pulmonary metastasectomy in solid tumors: a single-center experience at a tertiary referral center in the Middle East

Despite advances in systemic therapy, pulmonary metastasectomy remains a key option for selected patients with metastatic solid tumors, offering long-term survival. Prognosis is influenced by many factors including disease-free interval and metastatic burden. This study evaluates...