King George's Medical University

A Pilot Study on the Effect of In Vitro-Induced Antibiotic Resistance on Biofilm Formation by Uropathogenic Escherichia coli

Biofilm formation by uropathogenic Escherichia coli contributes to antibiotic resistance and the persistence of urinary tract infections. Whether biofilm formation is an intrinsic characteristic of UPEC or an adaptive response to antibiotic stress remains unclear, as does whether...

Reimagining mentorship in competency-based dental education: An AI-enabled mentoring network framework

Mentoring is increasingly recognized as a critical determinant of academic achievement, professional identity formation, career advancement, and well-being in health professions education. Conventional mentor-mentee models, typically centered on a single assigned faculty mentor,...

Association of radiation caries burden with time elapsed since completion of radiotherapy in patients with head and neck cancer: A cross-sectional pilot study

Objectives: To assess the burden of dental caries using the Decayed (D) component of the DMFT index and to evaluate its association with time elapsed since completion of radiotherapy. Material and Methods: A cross-sectional pilot study involving 37 head and neck cancer patients w...

Efficacy and Safety of EG12014 (Biosimilar Trastuzumab) Compared to Reference Trastuzumab in HER2-Positive Early Breast Cancer: A Phase III Randomized Study

Trastuzumab biosimilar EG12014 (Herwenda ® ; EirGenix/Sandoz) was approved by the European Medicines Agency (EMA) in 2023. We aim to demonstrate equivalent efficacy, and to compare safety, immunogenicity, and pharmacokinetic (PK) profiles, of EG12014 and reference trastuzumab (re...

Oral health and the risk of dementia: a systematic review, meta-analysis, and comparative evaluation against established systemic risk factors

Oral health has been increasingly associated with dementia and cognitive decline, but the magnitude and consistency of associations across distinct oral-health domains remain unclear. We systematically evaluated domain-specific associations between oral health conditions and deme...

Association between parental socioeconomic characteristics and overweight and obesity among adolescents

OBJECTIVES: Adolescent overweight and obesity are rising global concerns, with prevalence increasing from 8 % in 1990 to 20 % in 2022. In India, adolescents constitute 21 % of the population and face growing risks of obesity-related complications. Parental education and occupatio...

Immunohistochemical and Molecular Analysis of Occludin, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform and Scribble Planar Cell Polarity Protein in Oral Squamous Cell Carcinoma Progression: A Three-Marker Exploratory Study

Oral squamous cell carcinoma (OSCC) remains a significant global health concern due to its poor prognosis and late-stage diagnosis. Identifying reliable molecular markers may improve prognostication and therapeutic decision-making. In this study, the expression of Occludin (OCLN)...

Genome-wide association analysis of endometriosis in Indian women supports shared genetic susceptibility and suggestive population specific signals

Endometriosis is an estrogen-dependent, chronic gynaecological disorder affecting approximately 10% of women of reproductive age and is associated with pelvic pain, infertility, and reduced quality of life. Genetic studies indicate substantial heritability, yet genome-wide associ...

Adaptive multi-scale attention-enhanced V-NET for accurate and efficient multi-shell diffusion MRI estimation

Multi-shell acquisition protocols sample diffusion signals at different b -values. While higher b -values (e.g., \(b = 2000\, \mathrm {s/mm^2}\) ) offer increased sensitivity to microstructural features, their acquisition is time-intensive and suffers from reduced signal-to-noise...

miR-451a is a differentially expressed blood-based microRNA in newly diagnosed CML identified by high-throughput profiling

Abstract Background microRNAs (miRNAs) are emerging as promising biomarkers in hematological malignancies due to their stability in blood. This study aimed to investigate the differential expression of miRNAs in chronic myeloid leukemia (CML) and evaluate the potential of miR-451...

P1.241. Comparative Outcomes of Triple-Layer Hand-Sewn Versus Double Linear Stapled Cervical Esophagogastric Anastomosis Following Minimally Invasive Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Cervical anastomosis after esophagectomy carries leak rates approaching 30%. Although the choice between stapled and hand-sewn techniques is often based on surgeon preference, existin...

Sleep and Stroop Performance with Adjunctive Melatonin in Pharmacotherapy-stable Pediatric ADHD: A Prospective Open-label Study

Background: Attention-deficit/hyperactivity disorder (ADHD) is frequently comorbid with sleep disturbances; evidence linking melatonin to objective neurocognitive outcomes in this population is lacking. The present study assessed the association of melatonin with parent-reported...

Clinicopathological and Prognostic Implications of Circulating MicroRNA-429 in Breast Cancer Patients

Abstract Background/Aims: MicroRNA-429 (miR-429), a member of the miR-200 family, has been implicated in epithelial–mesenchymal transition and tumor progression, yet its clinicopathological significance in breast cancer remains unclear. This study aimed to evaluate serum miR-429...

Efficacy of Chest Radiograph in Comparison to no Intervention in Screening for Lung Cancer in People who Smoke: A Systematic Review

ABSTRACT: Smoking is the primary risk factor for lung cancer, which remains one of the leading causes of cancer-related mortality worldwide. Although chest radiography (CXR) is widely available and inexpensive, its role in lung cancer screening remains uncertain. This systematic...