King Edward Medical University

Real-world safety and effectiveness of empagliflozin (Diampa®) alone or in combination with metformin (Diampa-M®) in patients with type 2 diabetes mellitus in Pakistan: a multicenter observational study

Abstract Background Type 2 diabetes mellitus (T2DM) is a growing public health challenge in Pakistan, where poor glycemic control is common. Sodium–glucose co-transporter 2 (SGLT2) inhibitors, such as empagliflozin, have shown glycemic, cardiovascular, and renal benefits in contr...

Comparative Effectiveness and Safety of Low Molecular Weight Heparin, Rivaroxaban, Apixaban, and Warfarin in Postoperative Thromboprophylaxis and Deep Vein Thrombosis Management: A Systematic Review and Meta-Analysis

ABSTRACT: Prophylactic venous thrombosis or more commonly known as postoperative "blood clots" is a problem in all surgeries and is known as venous thromboembolism or VTE, and continues to be a significant cause of postoperative morbidity and mortality. For the prevention and tre...

Multilingual Hematology Visual Question Answering Dataset

Vision Language Models (VLMs) have shown promising capabilities in medical image analysis by jointly understand- ing visual and textual information for tasks such as Visual Question Answering (VQA). However, existing hematology vision-language resources remain predominantly Engli...

Anesthetic Approaches for Left Atrial Appendage Occlusion: Comparing Conscious Sedation and General Anesthesia: A Meta Analysis

Background Left atrial appendage occlusion (LAAO) offers a mechanical alternative to anticoagulation for stroke prevention in nonvalvular atrial fibrillation patients. However, the optimal anesthetic strategy—general anesthesia (GA) versus conscious sedation (CS)—during LAAO rema...

Efficacy and Safety of Sacituzumab Govitecan for Breast Cancer

Objectives: Sacituzumab govitecan (SG), a Trop-2-directed antibody-drug conjugate, has demonstrated clinical activity in HER2-negative breast cancer. Our meta-analysis aimed to evaluate the efficacy and safety of SG compared with standard chemotherapy in patients with breast canc...

Evaluating the Impact of Surface Treatments on a Fluorinated Silicon Phthalocyanine Organic Mixed Ionic-Electronic Conductor

Abstract Small-molecule organic mixed ionic-electronic conductors (OMIECs) offer an interesting alternative to polymers for the fabrication of reliable organic electrochemical transistors (OECTs) thanks to their minimal batch-to-batch variability. The environmental and operationa...

Preoperative SGLT2 Inhibitor Use and Outcomes After Major Cardiac Procedures: A Propensity Score-Matched Analysis of the TriNetX Network

Background/Objectives: Sodium–glucose cotransporter-2 (SGLT2) inhibitors improve cardiorenal outcomes in patients with diabetes, heart failure, and chronic kidney disease. Their association with perioperative outcomes after major cardiac procedures remains uncertain. Methods: In...

Efficacy of rituximab plus lenalidomide regimens in follicular lymphoma: a meta-analysis of randomized controlled trials

Follicular lymphoma (FL) is an incurable, indolent non-Hodgkin lymphoma with a high relapse rate despite effective chemoimmunotherapy. Lenalidomide, an immunomodulatory agent, in combination with rituximab (R²), has been evaluated as an alternative to chemoimmunotherapy and to ot...

Umbilical port versus epigastric port for gallbladder extraction in laparoscopic cholecystectomy. An updated systematic review and meta-analysis

Laparoscopic cholecystectomy (LC) is the gold standard for gallstone disease, but the optimal extraction port (umbilical vs. epigastric) remains debated. This updated systematic review and meta-analysis aimed to evaluate whether port site selection impacts perioperative and posto...

Comparative efficacy and safety of oral iron polymaltose complex vs. ferrous sulphate in the treatment of pediatric iron deficiency anemia: a systematic review, meta-analysis and trial sequential analysis

Oral iron supplementation is the first-line therapy for pediatric iron deficiency anemia (IDA). Ferrous sulphate (FS) remains the conventional standard of care but frequently induces gastrointestinal (GI) adverse effects. Iron polymaltose complex (IPC) has emerged as an alternati...

Microplastics and colorectal cancer: presence in human colorectal tissues and associations with tumor biology

The incidence and death rates of colorectal cancer (CRC), one of the world’s largest health issues, are rising. These days, environmental contaminants such microplastics (MPs) are believed to play a role in the development of colorectal cancer. Small plastic particles (less than...

Association of oral vancomycin prophylaxis with Clostridium difficile infection in hematopoietic stem cell transplant recipients: A systematic review and meta-analysis

Background: Clostridium difficile infection (CDI) occurs in up to 30% of hematopoietic stem cell transplant (HSCT) recipients and remains a significant cause of infectious diarrhea. This meta-analysis evaluated the association of oral vancomycin prophylaxis (OVP) with CDI prevent...

Ropeginterferon alfa-2b in Polycythemia Vera: A systematic review and meta-analysis

Background: Ropeginterferon alfa-2b, a novel monopegylated interferon with improved pharmacokinetics, has emerged as a promising cytoreductive agent for managing polycythemia vera (PV). Despite increasing adoption, evidence synthesis of its efficacy and safety compared to standar...