King Edward Medical University

Microplastics and colorectal cancer: presence in human colorectal tissues and associations with tumor biology

The incidence and death rates of colorectal cancer (CRC), one of the world’s largest health issues, are rising. These days, environmental contaminants such microplastics (MPs) are believed to play a role in the development of colorectal cancer. Small plastic particles (less than...

Ropeginterferon alfa-2b in Polycythemia Vera: A systematic review and meta-analysis

Background: Ropeginterferon alfa-2b, a novel monopegylated interferon with improved pharmacokinetics, has emerged as a promising cytoreductive agent for managing polycythemia vera (PV). Despite increasing adoption, evidence synthesis of its efficacy and safety compared to standar...

Association of oral vancomycin prophylaxis with Clostridium difficile infection in hematopoietic stem cell transplant recipients: A systematic review and meta-analysis

Background: Clostridium difficile infection (CDI) occurs in up to 30% of hematopoietic stem cell transplant (HSCT) recipients and remains a significant cause of infectious diarrhea. This meta-analysis evaluated the association of oral vancomycin prophylaxis (OVP) with CDI prevent...