King Abdullah International Medical Research Center

From Infection to Oncology: AI-Assisted Drug Repurposing Uncovers Anti-Infective and Excipient-Class Compounds as PPAR-α-Linked Anticancer Agents

Drug repurposing offers an efficient strategy to identify novel anticancer agents from marketed compounds. We screened a library of ~1400 approved drugs using a PPARE–PPAR-α luciferase reporter assay to uncover modulators of lipid metabolism that induce cancer cell death without...

Academic educators’ leadership styles and their associations with student engagement and critical thinking disposition among Saudi health sciences students: a mixed-methods study

Educator leadership behaviors are widely recognized as an important component of the classroom environment and may be associated with student engagement and critical thinking disposition. In health sciences education, these competencies are fundamental to clinical reasoning and e...

Artificial Intelligence-Enhanced Spirometry in Primary Healthcare: Opportunities for Early Detection of Small Airway Dysfunction

Spirometry underuse and persistent limitations in its technical quality and interpretation in primary healthcare (PHC) contribute to delayed and inaccurate diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Artificial intelligence (AI) has recently demonstrated...

Assessing the osteoporosis care gap and clinical outcomes following fragility hip fractures in Saudi Arabia: implications for fracture liaison services

Abstract Background Osteoporotic hip fractures cause significant morbidity, mortality, and healthcare burden. Substantial gaps persist in osteoporosis diagnosis and secondary fracture prevention, particularly in Saudi Arabia. Aims To evaluate the osteoporosis care gap, mortality...

Changes in Glycemic Control and Lipid Profiles Following COVID-19 Infection in Adults with Type 2 Diabetes: A Retrospective Study in Saudi Arabia

Background: The clinical course and mortality risk of COVID-19 in patients with type 2 diabetes (T2D) remain elevated. Understanding its pathogenesis is essential for prognostic and therapeutic strategies. Viral infections can disrupt host glucose and lipid metabolism. This study...

Maternal satisfaction and childbirth experience in anaesthesia assisted and non anaesthesia assisted labour: a comparative study in Jeddah, Saudi Arabia

Abstract Background Maternal satisfaction during childbirth is a multidimensional concept influenced by pain management, perceived control, emotional support, and overall birth experience. Although neuraxial anaesthesia is effective in relieving labour pain, its impact on overall...

Metabolic Signatures Associated with COVID-19 Vaccination in Serum from Healthy Individuals

Background: COVID-19 vaccines have proven effective in reducing severe disease and mortality from SARS CoV-2 infection. The underlying molecular mechanisms and alterations in the human serum metabolome influencing the effectiveness and development of immunity remain unclear. Meth...

The clinical presentation and outcomes of dengue fever: a review of a tertiary care center in Saudi Arabia

Dengue fever (DF) is a viral infection spread by mosquitoes and is one of the most frequently reported infectious diseases in Saudi Arabia, particularly in Jeddah. Despite recurring outbreaks, recent data on the clinical characteristics, seasonal variation, and outcomes of affect...

In vitro study and in silico reveal Teucrium Polium L. methanolic extract as an apoptosis inducer and a potential Bcl-2 inhibitor for breast cancer

Therapy of breast cancer (BC) overexpressing the pro-survival protein Bcl-2 remains a major clinical challenge. The discovery of natural anticancer drugs with potential as Bcl-2 inhibitors has generated increasing interest. The medicinal plant Teucrium polium L. (TPL) exhibits ph...

Exploring the Link: A Study on Consanguinity and Orofacial Clefts

Objective To evaluate the association between parental consanguinity and cleft phenotype, family history, syndromic status, regional distribution, and sex-specific presentation among Saudi patients affected by cleft lip and/or palate (CL/P). Design Retrospective cross-sectional o...

National Trends in Gender Representation, Segregation, and Disparities in the Saudi Dental Workforce, 2016–2025

Introduction and aims Despite the importance of gender equity for promoting fairness and informing workforce planning, key indicators of gender equity in the Saudi dental workforce remain underexplored. This study assessed gender representation in the Saudi dental workforce from...

Cross-cultural adaptation of cancer health literacy instruments in Arabic: the CHLT-30-Arabic and CHLT-6-Arabic

Background Health literacy plays a crucial role in physical and mental health outcomes. Patients with chronic diseases, cancer patients in particular, shoulder a disproportionate burden due to limited health literacy. Limited cancer health literacy (LCHL) is a risk factor for dis...

Predicting the Unwelcome Return: Insights From a Cohort of Postoperative Haemorrhoid Patients

AIM: Recurrence after haemorrhoid surgery is a clinical concern, but the factors associated with recurrence have not yet been fully elucidated. In particular, the effects of external haemorrhoids and postoperative complications on long-term outcomes have not been clearly defined....

Sphenoid fungal rhinosinusitis across the disease spectrum: a case series of non-invasive fungal ball and fatal acute invasive fungal rhinosinusitis

Introduction: Sphenoid fungal rhinosinusitis is an uncommon but clinically important entity ranging from non-invasive fungal ball to rapidly fatal acute invasive fungal rhinosinusitis. Case presentation: We report two contrasting cases of sphenoid fungal disease. The first was a...

Role of consolidative surgery after chemotherapy in recurrent/metastatic adrenal cortical cancer (ACC): Princess Margaret Cancer Centre experience

Recurrent/Metastatic (R/M) ACC is aggressive with few effective treatment options. The role of surgery after chemotherapy remains unclear. Moreover, prognostic factors in R/M ACC are not well defined. R/M ACC patients treated at Princess Margaret Cancer Centre (2002–2019) were re...