Kidney Associates

Lactate drives maladaptive metabolic reprogramming via MRS2 in ischemia/reperfusion-induced acute kidney injury

Ischemia/reperfusion (I/R) triggers profound bioenergetic collapse in renal proximal tubular epithelial cells (PTECs), inducing acute kidney injury (AKI) and forcing a sustained shift from mitochondrial oxidative metabolism to glycolysis. Lactate accumulation is a hallmark of thi...