Khyber Medical University

Antidiabetic and renal biochemical effects of 70% aqueous methanolic Chenopodium murale extract in alloxan-induced diabetic rats

Abstract With the increasing prevalence of diabetes mellitus (DM), there is growing interest in affordable plant-derived products with potential antidiabetic activity. Chenopodium murale L. (CM) contains bioactive phytochemicals with reported antioxidant and metabolic effects, bu...

The Glymphatic System in Traumatic Brain Injury, Subarachnoid Hemorrhage, and Neurodegeneration: A Unifying Neurobiological Framework

Whether glymphatic dysfunction drives or merely follows brain injury and neurodegeneration remains unresolved. The glymphatic system mediates the transport, exchange, and clearance of solutes between cerebrospinal fluid (CSF) and interstitial fluid (ISF) through paravascular CSF...

Kartagener syndrome with pulmonary mycetoma and recurrent thromboembolism

Rationale: Kartagener syndrome, a variant of primary ciliary dyskinesia, is defined by chronic sinusitis, bronchiectasis, and situs inversus. While recurrent infections are seen, a combination of thromboembolic disease, pulmonary mycetoma, cardiac dysfunction, and serological evi...

High-flow nasal cannula versus conventional oxygen therapy in adults with acute hypoxemic respiratory failure: an updated systematic review, meta-analysis and trial sequential analysis

HFNC oxygen therapy is widely used for acute hypoxemic respiratory failure (AHRF), yet its superiority over conventional oxygen therapy (COT) remains uncertain. This meta-analysis evaluated HFNC efficacy and safety in adults with AHRF. Five databases were searched from January 20...

Critical Appraisal: “Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study”

Data sharing does not apply to this article as no datasets were generated during the current study; All data were sourced from published literature.

Ecophysiology and Behavioral Indicators of thermal Stress in Freshwater Crab Himalayapotamon emphyseteum Under Experimental Warming

Global warming poses substantial challenges to ectothermic organisms, which depend on physiological and behavioural adjustments to maintain homeostasis under thermal stress. We examined the effects of experimental warming on oxygen consumption, ammonia excretion, feeding activity...

Efficacy of rituximab plus lenalidomide regimens in follicular lymphoma: a meta-analysis of randomized controlled trials

Follicular lymphoma (FL) is an incurable, indolent non-Hodgkin lymphoma with a high relapse rate despite effective chemoimmunotherapy. Lenalidomide, an immunomodulatory agent, in combination with rituximab (R²), has been evaluated as an alternative to chemoimmunotherapy and to ot...

Ropeginterferon alfa-2b in Polycythemia Vera: A systematic review and meta-analysis

Background: Ropeginterferon alfa-2b, a novel monopegylated interferon with improved pharmacokinetics, has emerged as a promising cytoreductive agent for managing polycythemia vera (PV). Despite increasing adoption, evidence synthesis of its efficacy and safety compared to standar...

Association of oral vancomycin prophylaxis with Clostridium difficile infection in hematopoietic stem cell transplant recipients: A systematic review and meta-analysis

Background: Clostridium difficile infection (CDI) occurs in up to 30% of hematopoietic stem cell transplant (HSCT) recipients and remains a significant cause of infectious diarrhea. This meta-analysis evaluated the association of oral vancomycin prophylaxis (OVP) with CDI prevent...