Kepler Universitätsklinikum

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Intratumoral desmoplastic stroma in carcinoma brain metastases harbors stromal cells with a cancer-associated fibroblast (CAF)-like immunophenotype

Abstract Background Research on the tumor microenvironment of brain metastases (BM) has largely focused on immune response, while the intratumoral stromal compartment remains poorly characterized. In primary carcinomas, cancer-associated fibroblast (CAF) are intratumoral stromal...

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

Artificial General Intelligence (AGI) A1–A5 Grading Standard: From Embedded Tool to Life-Level Civilization Partner

This paper proposes a five-level grading standard (A1 to A5) for Artificial Gen-eral Intelligence (AGI), aiming to characterize the complete evolutionary path of AGI from an Embedded Tool to a Life-Level Civilization Partner. This standard goes beyond a single dimension centered...

Artificial General Intelligence (AGI) A1–A5 Grading Standard: From Embedded Tool to Life-Level Civilization Partner

This paper proposes a five-level grading standard (A1 to A5) for Artificial Gen-eral Intelligence (AGI), aiming to characterize the complete evolutionary path of AGI from an Embedded Tool to a Life-Level Civilization Partner. This standard goes beyond a single dimension centered...

Feasibility of Electrode-Location Estimates Based on Preoperative CT-Imaging for Anatomy-Based Fitting in Cochlear Implant Recipients

OBJECTIVES: To investigate whether there is a difference between electrode frequencies estimated in OTOPLAN according to anatomy using a preoperative CT scan and electrode frequencies based on postoperative cone beam computer tomography (CBCT). STUDY DESIGN: Monocentric retrospec...

Incidence and epidemiology of out-of-hospital cardiac arrest in Upper Austria

Summary Objective To determine the incidence and epidemiology of out-of-hospital cardiac arrest (OHCA) with resuscitation attempts by emergency physician teams in Upper Austria. Methods This multicenter, retrospective study included all OHCA cases attended by all 22 physician-sta...

Duration of Resuscitation and Survival of Pediatric Traumatic Cardiac Arrest

Objectives: To evaluate the association between resuscitation duration and survival from pediatric traumatic cardiac arrest (TCA). Methods: A meta-analysis was conducted. CENTRAL, MEDLINE, and EMBASE were searched from January 1, 2000, to January 31, 2026. Eligible studies includ...

Does time matter? Rethinking the Temporal Dimension of Psoriasis

Soo Bin Ahn, Claudia Furtmüller, Emmanuella Guenova, Wolfram Hoetzenecker; Does time matter? Rethinking the Temporal Dimension of Psoriasis, British Journa

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Radiological response of primary central nervous system lymphoma after corticosteroid therapy and its predictive value on overall survival: a multicenter study

Abstract Background Primary Large-B-Cell Lymphoma of the CNS (PCNS-LBCL) is a rare, aggressive tumor often sensitive to corticosteroid therapy (CST). This multicenter study investigated the spectrum of radiological responses to routine CST and evaluated its impact on patient prog...

Association between adherence patterns to antifibrotic therapy and survival in fibrotic interstitial lung disease: a nationwide Austrian health claims study

Antifibrotic therapies slow disease progression in patients with progressive fibrosing interstitial lung diseases (PF-ILD). However, long-term adherence is difficult to maintain mainly due to side effects. Real-world data on adherence and its association with prognosis are still...

Screening for amyloidosis in trigger finger release and Dupuytren’s fasciectomy

INTRODUCTION: This study investigated the prevalence of amyloid deposition in tissue obtained during trigger finger release and limited fasciectomy for Dupuytren's disease and whether these procedures may allow early detection of cardiac amyloidosis. METHODS: This prospective, ex...

High-fidelity animal model simulation improves surgical competence in medical students

To determine whether a formal suturing simulation course using a realistic animal model improves medical students’ perception of their technical competence and their later self-confidence in a competency-based model of surgical education. The opportunities to acquire hands-on tra...

Nutritional intake and growth in very low birth weight infants: a comparison of standardized versus parent-led complementary feeding

Abstract The complementary feeding (CF) period is critical for ensuring adequate nutrient intake to support optimal growth in very low birth weight (VLBW) infants. This analysis compares nutritional intake and growth across two CF strategies: a standardized, protocol-driven appro...

DNA methylation of silencer-annotated regions at the MGMT locus in the context of promoter and enhancer methylation in glioblastoma and melanoma brain metastases

Abstract Background MGMT promoter methylation is a well-established biomarker in glioblastoma, its relevance in melanoma brain metastases remains controversial. Recent studies indicate that methylation of MGMT enhancers contributes to MGMT regulation, whereas the role of silencer...