Kenyatta National Hospital

A User-Centered Approach to Customizing, Validating, and Evaluating a Large Language Model for Empowering Healthcare Providers with Up-to-Date Information on Adolescent and Child Health

Healthcare professionals (HCPs) in Kenya face critical challenges in accessing reliable, context-specific information on adolescent and child health, which hampers clinical decision-making and compromises patient outcomes. Large Language Models (LLMs) offer a promising solution b...

One-year outcomes and intervention waiting time of patients admitted with congenital heart disease at Kenyatta National Hospital, Kenya

Congenital Heart diseases (CHD) are clinically significant structural heart disease present at birth. CHD is found in 8–15 babies per 1,000 live births. Delayed diagnosis and long waiting time to intervention may lead to poor outcome. The objective was to establish the one-year p...

An Fc receptor and IgA functional signature identifies TB disease in children living with HIV

Abstract Background Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). TB disease is difficult to detect with current clinical microbiological, immunological, and radiographic tools. Serological assays that determine levels of...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Pharmacist-supported audit and feedback intervention to reduce Gentamicin prescribing errors in neonatal inpatient care in Kenya: a natural experiment using interrupted time series analysis

Abstract Background Approximately 14.9% of medications prescribed during hospital care in low- and middle-income countries (LMICs) contain errors, with neonates who experience high morbidity and mortality in these settings being particularly vulnerable. Gentamicin, a common first...

International migration of Africa-born health workers: a scoping review of drivers and policies, 2010–2024

Africa faces a critical shortage of human resources for health (HRH), crucial for improving population health. We described drivers of and policies to manage the migration of Africa-born HRH from source (African) countries in Africa to destination (non-African) countries. We cond...

Retrospective study of traumatic brain injury cases

Objectives: The global annual incidence of traumatic brain injury (TBI) is predicted to reach 69 million cases. The World Health Organization indicates that about 10 million annual cases of TBI result in death or significant disability. The incidence of morbidity and mortality du...