Kent County Council

Functional Activity of TDP-43: A Direct Biomarker for ALS

TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synth...

Eye Movement Desensitization and Reprocessing (EMDR) for Shame Related Offense Trauma in a Justice Involved Individual Presenting With Active Suicidality and Self‐Harm

A single-case study is presented, which describes the application of EMDR for a justice involved health care worker, presenting with active suicidality and self-harm, within the context of high levels of offense-related shame. "Alex" was a 42-year-old female, serving a prison sen...