KEMRI-Wellcome Trust Research Programme

Africa’s first standard measure for child and adolescent health: The Nigerian EQ-5D-Y-3L value set using composite time trade-off and discrete choice experiments

Nigeria has a rapidly growing child and adolescent population, yet no locally derived EQ-5D-Y-3 L utility weights (value set) exists for estimating quality-adjusted life years (QALYs) in paediatric economic evaluations. This study developed the first Nigerian EQ-5D-Y-3 L value se...

Maternal healthcare quality, continuity, and experiences among pregnant adolescents and adult women in Ethiopia, Kenya, and South Africa: A cohort study

The capacity of health systems to provide quality care for pregnant adolescents remains underexplored. This study examined the quality, continuity, and experiences of maternal healthcare among pregnant adolescents (<20 years) compared with adult women (20 + years) in Ethiopia, Ke...

Machine learning models to predict low birth weight in the Kenyan Coast

Low birth weight (LBW, < 2500 g) is associated with poor outcomes across multiple domains of child development. Predicting high-risk pregnancies for LBW will therefore enable timely intervention. We aimed to develop and internally validate machine learning models to predict LBW i...

Spatial surveillance of Plasmodium falciparum Kelch 13 mutations reveals High-Frequency A675V and the First Molecular Evidence of Suspected Partial Artemisinin Resistance in Baringo in Kenya

Abstract Background This surveillance study evaluated the polymorphisms of Pfk13 gene in samples from symptomatic individuals from eight geographically distinct locations in Kenya to determine the prevalence of mutations associated with partial artemisinin resistance. Methods Bet...

Prevalence and determinants of death registration across three demographic surveillance sites in Kenya

Abstract Background Death registration remains markedly incomplete in many low- and middle-income settings despite its importance in generating population statistics for health systems planning and monitoring of sustainable development goals. We assessed the completeness of death...