Keele University

Inside the ‘Black Box’ of Pharmaceuticalisation: NICE, the Permissive Principle and the Case of Anticoagulants

Sociological interest in pharmaceuticalisation continues to grow, especially regarding the expansion of pharmaceutical use in society. This article presents the first major empirical study focusing on the directionality of pharmaceuticalisation by taking cost-effectiveness assess...

Clinical examination findings were not associated with isometric strength or functional performance in adults with groin pain

Abstract Objectives The aim of this study was to investigate whether positive clinical examination findings were associated with selected measures of lower-limb isometric strength or functional performance in physically active adults with groin pain. Methods This was a cross-sect...

EMU detection of mysterious multiple component radio-continuum emission from nearby spiral Seyfert I type galaxy ‘Sand-timer’ (NGC 7213)

We present an Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) radio-continuum detection of the nearby spiral Seyfert I type galaxy NGC 7213 which we nickname ‘sand-timer’ due to its morphological appearance. We find an intriguing and pe...

Scalable Multi-UAV Target Assignment via Permutation-Invariant Reinforcement Learning and Conditional Control-Barrier-Function Safety Filtering

Coordinating multiple unmanned aerial vehicles (UAVs) to assign targets and generate collision-free trajectories in dynamic, obstacle-dense environments is a challenging problem with applications in search-and-rescue, surveillance, and precision agriculture. Existing deep reinfor...

Navigating sensitive content in secondary English: teachers’ use of content warnings when teaching Shakespeare

This article reports on a small-scale mixed methods survey, conducted as part of a larger funded project, examining how secondary English literature teachers approach violence and other potentially disturbing material in Shakespeare’s plays. Forty teachers in England completed an...

Validation of the MSK-HQ in a hand therapy setting

Objectives There is a shortage of clinical tools integrating the individual journey through healthcare, as care providers frequently use diverse Patient Reported Outcome Measures (PROMs) that cannot be easily aggregated. The use of a single PROM from primary care into tertiary ca...

Feminist team teaching

Feminist Team Teaching is the sixth best practice guide published by Doing Feminist Legal Work (DFLW) (p. 1). Readers are signposted to an interpretation of collegial and collective law teaching th...

Service-level and practitioner-level recommendations for better care of people with dementia who live alone and have no informal caregivers

Context A substantial proportion of people with dementia live alone without informal caregivers, yet services often assume family involvement, increasing risks of unmet need and adverse outcomes. Objective This study aimed to generate service-level and practitioner-level recommen...

Wave propagation and wrinkling localization in a prestressed periodic elastic half-space

We investigate surface waves in a prestressed elastic half-space whose material properties are constant in the vertical direction but vary periodically along the direction of wave propagation. Using Floquet-Bloch theory, Fourier expansion, and the Stroh formalism, we reduce the d...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

A refined decay condition for a high-contrast sandwich plate subject to antiplane shear

Abstract A three-layered elastic semi-infinite strip subject to antiplane shear is considered. The relative stiffness ratio is assumed to be a small parameter. The so-called decay conditions generalising the Saint-Venant’s principle are studied. A first-order asymptotic correctio...

Effectiveness of Adding GLP ‐1 Receptor Agonists to SGLT2 Inhibitor Therapy in Chronic Kidney Disease: A Population Based Study

ABSTRACT Background Individually, sodium–glucose co‐transporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have been shown to reduce major kidney and cardiovascular events in patients with chronic kidney disease (CKD). However, evidence support...

ACTIVATE: A protocol for a randomised controlled evaluation of Thumos: A cognitive-behavioural intervention for medical students

Background Medical students experience high rates of burnout and mental health distress, with approximately half reporting burnout, one-third experiencing depression, and one-tenth having suicidal thoughts. These issues are exacerbated during clinical placements and contribute to...

Treating Smn2B/− spinal muscular atrophy (SMA) mice with commercially approved metabolism-targeting interventions leads to improved disease phenotypes

Abstract Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular condition that is increasingly recognized as a multi-systemic disorder in which metabolic dysfunction plays a central role. Reframing SMA pathology from a neurocentric to a metabolic perspective reveal...

A Community-Based One Health Solid Waste Management Model in Ward 19, Lupane District, Zimbabwe

Abstract Poor solid waste management is an emerging challenge in many rural communities in Africa, with implications for environmental quality, human health, animal health, and local livelihoods. This case study documents the development and implementation of a community-based On...

Wild Boar-Related Injuries in Wilderness Environments: Field-Oriented Management Principles and Evidence-Informed Clinical Recommendations

Wild boar-related trauma is uncommon but may result in severe injuries that pose diagnostic and therapeutic challenges, particularly in wilderness or resource-limited environments. Most scientific literature consists of isolated case reports, regional series, and forensic descrip...

Strengthening evidence on migrant workers’ health in Nepal

Abstract Thousands of Nepalese labour migrants have died abroad in past decades, and morbidity is also high. The high volume of data collected through pre-departure health screening, unfortunately, remains largely unused. Making better use of health data, including by trusted pub...

An Enquiry on the Ethics of One Medicine

One Medicine is not One Health. Although both concepts connect animal and human health, One Health has arguably become a frame for public health. This paper argues that One Medicine uniquely centres on animal and human patients and speaks to the equal interdependence of their hea...

Football Cleats and Injury Patterns in 14- to 19-Year-Old Female Football Players: The Effect of Surface, Gender-Specific Shoe Gear and Cleat Pattern

BACKGROUND: Female football (soccer) players are at increased risk for lower extremity injuries, yet prevention strategies remain based mostly on male athlete data. Modifiable extrinsic factors including footwear design and playing surface have not been well defined in youth fema...

Your voice matters: using participatory film to engage people with chronic pain in public involvement and research

BACKGROUND: People living with chronic pain (≥ 3-months) often struggle to participate in valued activity (for example, family life, work and in their community) and are under-represented in public involvement and research. We aimed to broaden awareness and encourage engagement i...