KCMC University

Association between Plasmodium falciparum AMA-1, MSP-119, and GLURP- R2 IgG antibody responses and malaria transmission exposure in rural Tanga Region, north-eastern Tanzania

Malaria remains a significant health burden in sub-Saharan Africa despite ongoing control efforts. Antibody responses to key Plasmodium falciparum antigens— pf AMA-1, pf MSP-1₁₉, and pf GLURP-R2—serve as markers of exposure and immunity. However, data on their seasonal variation...

Distinct transcriptional remodeling of immune and metabolic pathways in severe undernutrition during latent tuberculosis infection does not consistently predict tuberculosis progression across independent cohorts

Background: Undernutrition increases tuberculosis (TB) risk, but whether severe undernutrition during latent TB infection (LTBI) produces blood transcriptional changes that resemble active disease or identify future TB remains unclear. Methods: We reanalyzed whole-blood RNA seque...

Prevalence of hepatitis B surface antigen and associated factors among long-distance truck drivers at the Tunduma One-Stop Border Post, Tanzania: a cross-sectional study at Tunduma, Tanzania

Hepatitis B virus (HBV) infection remains a major global public health concern and a leading cause of liver cirrhosis and hepatocellular carcinoma. Sub-Saharan Africa bears a disproportionately high burden of HBV infection. Long-distance truck drivers may be exposed to factors as...

Ethical and design considerations related to automated, confidential HIV testing invitations: insights from senders and recipients of SMS-based HIV testing invitations in Tanzania

Abstract Background Identifying individuals with undiagnosed HIV remains a global challenge. Mobile health (mHealth) approaches that leverage social networks hold potential to increase HIV testing uptake but also raise ethical considerations. Methods We conducted a qualitative st...

Perspectives of women and healthcare providers on facilitators and barriers to cervical cancer screening in the rural Kilimanjaro region Tanzania: a qualitative study

BACKGROUND: Cervical cancer can be prevented and treated if detected early through regular screening. However, 88% of women aged 30 to 49 have never been screened in Tanzania. OBJECTIVE: This study explored facilitators and barriers to cervical cancer screening among women and he...

Pesticide use safety practices and knowledge gaps among small-scale farmers, retailers and healthcare providers in Tanzania

Agriculture is a cornerstone of Tanzania’s economy, with most production driven by small-scale farmers. In efforts to manage pest-related crop losses, pesticide use has increased significantly, heightening concerns related to human health, environmental sustainability, and regula...

Recurrence of preinvasive cervical lesion and associated factors among women who underwent loop electrosurgical excision procedure at Kilimanjaro Christian Medical Centre hospital, northern Tanzania

BACKGROUND: Cervical cancer is a significant public health problem. Diagnosing preinvasive cervical lesion provides an important opportunity in early intervention to prevent progression to cervical cancer. Despite the achievements made in screening and management, the burden of c...