Kazusa DNA Research Institute

Transitioning from anonymous to real-name genetic testing in Japan: Implementation and implications for medical safety

Traditionally, genetic testing in Japan has been conducted using coded or pseudonymized identifiers to protect patient privacy. However, the 2022 revision of the Japanese Association of Medical Sciences guidelines emphasized integrating genetic information into routine clinical i...

Pan-genomic analysis reveals structural variations in AcLIS1 and a key residue variation in AcAAT1 driving pineapple linalool, ester, and lactone profiles

Abstract Pineapple (Ananas comosus) exhibits a diverse array of aromatic profiles—ranging from "Peach" and "Coconut" to "Sweet/Fruity" and "Floral/Citrus"—which are critical for consumer preference. However, the genetic and molecular mechanisms governing these key volatiles have...

A CRC–MYB chromatin loop controls auxin-mediated nectary growth in Arabidopsis

Abstract Floral nectaries, typically located at stamen bases, secrete sugar-rich nectar containing diverse secondary metabolites. Despite their defined position and specialized function, the mechanisms governing nectary formation remain unclear. Using publicly available single-nu...

DNA markers for newly discovered genetic loci Phr3 and Phr4 , conferring resistance to white rust in Chrysanthemum morifolium

Chrysanthemum white rust, caused by Puccinia horiana, poses a serious threat to chrysanthemum (Chrysanthemum morifolium) production. The development of resistant cultivars is of great interest to breeders. Owing to the polyploid nature and complex inheritance patterns of chrysant...

Early administration of calcineurin inhibitors limits tolerogenic effect of PTCy in allogeneic hematopoietic transplant

We recently demonstrated early administration of calcineurin inhibitors (CNIs) after murine allogeneic hematopoietic cell transplantation (allo-HCT) inhibits terminal exhaustion of donor T cells and hampers tolerance induction. However, the role of CNIs in regulating T-cell exhau...