Kazan State Medical University

Analytical Strategies for the Identification and Differentiation of Positional Isomers of N ‐(2‐Methoxybenzyl)‐2‐(trimethoxyphenyl)ethanamines by Chromatography and Mass Spectrometry

ABSTRACT N ‐(2‐Methoxybenzyl)‐2‐(trimethoxyphenyl)ethanamines (TMPEA‐NBOMe series) constitute a relatively new group of synthetic compounds, some of which are known as psychotomimetics on the illicit drug market and are subject to legal control in many countries (e.g., N ‐(2‐meth...

Metagenomic and Metabolomic Signatures of Gut Microbiota After Helicobacter pylori Eradication Therapy Supplemented with Butyric Acid and Inulin: Observational Study

The long-term impact of eradication therapy for Helicobacter pylori on the gut microbiota is a subject of significant interest. To evaluate the influence of the bismuth-based quadruple H. pylori eradication therapy supplemented with butyrate and inulin on functional alterations w...

Re-Evaluating Multi-Kinase Inhibitors Targeting FGFR and VEGFR Pathways for Combined Therapy in Colorectal Cancer: A Preclinical Study

Background: Overexpression and increased activity of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1/P-gp), breast cancer resistance protein (ABCG2/BCRP), and multidrug resistance-associated proteins (ABCC/MRPs), are known to be among the major contributors...

Diluted Aqueous DNA Solutions: Physicochemical and Biological Properties

Abstract Using a complex of physicochemical methods (dynamic and electrophoretic light scattering, UV spectroscopy, fluorescence, ORP measurement) and ecotoxicological tests, diluted aqueous solutions of salmon milt DNA (DNA-ml)—an accessible byproduct of the fishing industry wit...

Machine Learning-Assisted SHG Morphometry Reveals Distinct Collagen Microarchitectures of Trabecular Bone and Fibrosis in Bone Marrow Biopsies

Abstract Collagen microarchitecture in bone marrow biopsies represents a largely underexplored source of quantitative biomarkers for histopathological diagnostics and analysis of tissue remodeling. While second harmonic generation (SHG) microscopy has been increasingly applied to...