Kassala University

Association of metformin use with vitamin B12 deficiency and peripheral neuropathy in type 2 diabetes mellitus: a systematic review and meta-analysis

Abstract Background Metformin is the first-line pharmacological therapy for type 2 diabetes mellitus (T2DM). However, long-term use has been associated with reduced serum vitamin B12 levels, which may contribute to peripheral neuropathy — a common and debilitating complication of...