Kashan University of Medical Sciences

Changes in vision-related quality of life after cataract surgery and factors associated with preoperative VRQoL: a longitudinal study in older adults

Cataract is associated with reduced ability to perform everyday tasks, loss of independence, and diminished social participation. Clinical measures such as visual acuity do not capture the functional and psychosocial consequences of cataract. Vision-related quality of life (VRQoL...

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies

Ferroptosis, an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid peroxides, has emerged as a pivotal pathway in cancer biology and a promising therapeutic target. This review synthesizes the core molecular machinery governing ferroptos...

From knowledge to action: health literacy and health-promoting behaviors in parents of autistic children, a cross-sectional study in Iran

Children with Autism Spectrum Disorder (ASD) depend on their parents for their health and well-being, especially in Iran where formal services for children with ASD are limited and families play a central role in daily care. The most effective diagnostic and therapeutic intervent...

Met and unmet needs among older adults

Population ageing is increasing the demand for comprehensive health and social care services. Understanding the multidimensional needs of older adults, particularly unmet needs, is essential for identifying care gaps and developing targeted interventions. This study aimed to asse...

Timing of tracheostomy and hospital mortality in mechanically ventilated ICU patients: a prospective cohort study

Abstract Background The optimal timing of tracheostomy in mechanically ventilated critically ill patients remains controversial. Although early tracheostomy may reduce complications related to prolonged endotracheal intubation, its association with clinically important outcomes,...

Intermittent fasting in diabetic retinopathy: microbiome modulation, mechanisms, and clinical insights.

Intermittent fasting, a nonpharmacological approach, shows promise for controlling diabetic retinopathy but lacks concrete human evidence directly associating intermittent fasting with eye responses. This review highlights preclinical research insights about intermittent fasting...

Ecological analysis of Cutaneous leishmaniasis incidence and climatic variability in Kashan and Aran - Bidgol, Iran (2014–2024)

Cutaneous leishmaniasis (CL) is a major neglected tropical disease whose transmission is strongly influenced by climatic and environmental conditions. This study investigated the temporal associations between climatic variables and CL incidence in Kashan and Aran and Bidgol count...

The relationship between social anxiety and loneliness in older adults: a hierarchical regression and mediation analysis

The global population of older adults is growing at an unprecedented rate and is projected to exceed 2.1 billion by 2050. This demographic transition has made addressing this group’s mental and social health challenges, including loneliness and social anxiety, an urgent global pr...

Comparative effects of glucagon-like peptide-1-based regimens on peripheral arterial and limb events in type 2 diabetes: a network meta-analysis of randomized trials

Peripheral artery disease (PAD) is a disabling condition in patients with type 2 diabetes mellitus (T2DM), yet lower-extremity outcomes are rarely prespecified in trials of GLP-1-based therapies. We compared individual GLP-1-based regimens for PAD-related vascular and limb events...