Karaganda Medical University

Diagnostic performance of circulating microRNAs for the early diagnosis of different types of acute cerebrovascular disease

Early differentiation of acute cerebrovascular conditions is important for timely clinical management, while blood-based markers that could complement established diagnostic approaches remain under investigation. This exploratory case-control study evaluated the circulating expre...

Concordance of next-generation sequencing and conventional microbiology for pathogen detection and antimicrobial resistance prediction in pneumonia

Abstract Delays in pathogen and antimicrobial resistance (AMR) profiling adversely affect patient outcomes. Next-generation sequencing (NGS) may complement conventional microbiology (CM), yet real-world value of NGS in pneumonia diagnosis remains unclear. We quantified concordanc...

Biochemical Remodeling of Purine Metabolism and Lipid Peroxidation Across Thyroid Disease Phenotypes

Background and Objectives: Purine-metabolism profiles across distinct thyroid phenotypes remain poorly characterized despite the recognized redox imbalance associated with thyroid dysfunction and autoimmune thyroiditis (AIT). We compared plasma and erythrocyte purine-metabolite p...

Electrochemical Pretreatment of Chrysocolla for Enhanced Sulfidization and Flotation: Mechanism and Process Optimization

The flotation of oxidized copper minerals is limited by poor surface reactivity and the insufficient effectiveness of conventional sulfidization. This study investigated 50 Hz alternating current electrochemical pretreatment to enhance the sulfidization and flotation of chrysocol...

Inflammatory Bowel Disease in Kazakhstan: Phenotypes, Disease Activity, and Treatment Patterns from a National Registry

Background/Objectives: Inflammatory bowel diseases (IBDs) are an increasingly important global health problem, yet Central Asia remains underrepresented in international IBD data. To evaluate the clinical and demographic characteristics of patients included in the national multic...

Prospects for Physical Therapy in Rheumatoid Arthritis: Literature Review

Background: The incidence of rheumatoid arthritis is steadily increasing worldwide, resulting in a growing number of individuals who may lose the ability to perform self-care activities and professional duties, thereby reducing their quality of life. Rheumatoid arthritis represen...

MSC–Hydrogel Composite Systems for Knee Cartilage Repair and Osteoarthritis: A Systematic Review

Background: MSC–hydrogel composite systems were developed to overcome the poor cell retention and limited durability of conventional marrow stimulation and suspension-based MSC delivery. A rigorous synthesis of the clinical evidence is lacking. Objectives: To evaluate the safety...

Anti-Biofilm Activity of (+)-Endo-Borneol Against Streptococcus mutans: Experimental Evaluation, Virulence Gene Expression Analysis, and Molecular Docking

Streptococcus mutans is the primary etiological agent of dental caries due to its ability to form acidogenic biofilms on tooth surfaces. Natural monoterpenes have attracted considerable interest as potential antibiofilm agents for oral healthcare. The present study investigated t...