Karachi Medical and Dental College

Trends in perioperative mortality in the United States: A 25 year retrospective analysis

Background Perioperative mortality, defined as death within 30 days of surgery, is a significant global health concern. Despite improvements in surgical practices and anesthesia care, it continues to account for millions of deaths annually. This study examines trends in periopera...

Dexamethasone versus triamcinolone acetonide for the management of postoperative inflammation following cataract surgery

Background: Cataract remains the leading cause of reversible blindness worldwide, particularly in low-resource settings. Effective control of postoperative inflammation is essential to prevent complications such as cystoid macular edema and raised intraocular pressure. Dexamethas...

The missing link in NET regulation after splenectomy: Splenic control on neutrophil signalling in β‐thalassaemia/ HbE

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Exploring the Association Between Colorectal Cancer Metastasis and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Nationwide Analysis

Background: Metabolic syndrome-associated conditions and malignancies frequently co-exist, influencing each other’s progression, severity, and prognosis. This study evaluates whether metabolic dysfunction-associated steatotic liver disease (MASLD) contributes to an increased risk...

Myocardial Fibrosis in Pediatric Heart Disease

Myocardial fibrosis is increasingly recognized as a central determinant of adverse cardiac remodeling and long-term cardiovascular outcomes in children with congenital and acquired heart disease. Once considered an irreversible consequence of chronic myocardial injury, fibrosis i...