Kaohsiung Medical University

Cross-cultural measurement of social overload and social networking sites exhaustion: Rasch and DIF evidence from Ghana, Hong Kong, Türkiye

Social media research increasingly examines the psychological costs of constant connectivity, yet the cross-cultural comparability of widely used social overload and Social Networking Sites (SNS) exhaustion measures remains insufficiently tested. This study examined the dimension...

Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation

Lateral flow assays (LFAs) are widely used for point-of-care diagnostics, but their sensitivity is often limited by inefficient antibody orientation and poor signal transduction. Herein, we report a universal strategy integrating orientation-controlled antibody conjugation at the...

Endometrial microbial culture in the era of mNGS: a prospective cohort study of endometrial dysbiosis in women with infertility

Endometrial dysbiosis (ED) and chronic endometritis (CE) have gained increasing attention as potential risk factors for implantation failure and infertility. However, their diagnostic assessment remains heterogeneous, and the clinical roles of microbial culture and metagenomic ne...

Rh(III)-Catalyzed [4 + 2] Spiroannulation of 2-Phenylbenzimidazoles with Isomerizable 3-Methylmaleimides: Synthesis of Spiro-Fused Benzimidazoisoquinoline Succinimides

Abstract A Rh(III)-catalyzed exclusive [4 + 2] cascade cyclization of 2-phenylbenzimidazoles with 3-methylmaleimides for the synthesis of spiro-fused benzimidazoisoquinoline succinimides via C–H activation is reported. The detailed mechanistic study revealed that the reaction pro...

Co-exposure and interaction effect of a mixture of metals and polycyclic aromatic hydrocarbons on sperm oxidative damage

The study examined interactions between 16 polycyclic aromatic hydrocarbons (PAHs) and six metals in relation to sperm oxidative damage. PAH exposure was assessed using personal breathing-zone measurements, while metal exposure was quantified using urinary concentrations. Semen o...

A novel integrated circular radiography (ICRAD) phantom for evaluating non‐uniform image quality metrics in radiography

Abstract Background Anode heel effects have been shown to cause a non‐uniform distribution of X‐ray photon fluence, and anode angle could cause focal spot size variations across field. However, no previous study has investigated their effects on image quality metrics in radiograp...

Low-Supervision Asynchronously Monitored Home Rehabilitation for Adhesive Capsulitis: A Pilot Randomized Study

Background: Adhesive capsulitis often requires prolonged rehabilitation, and home exercise performed without supervision is difficult to document objectively. This pilot randomized trial evaluated the preliminary clinical effects and system-recorded engagement of a low-supervisio...

SGLT2i use and fracture risk compared with DPP4i in patients with T2DM

ABSTRACT Introduction The association between sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) use and fracture risk remains inconclusive. Most previous studies have focused on treatment‐naïve patients, despite many patients in routine clinical practice initiating SGLT2i therapy...

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

ABSTRACT Given the prominence of azetidine derivatives in pharmaceutical chemistry, developing their catalytic synthesis continues to attract strong attention from synthetic chemists. While the strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs...

Development and internal validation of a field-based triage tool for lumbopelvic-hip dysfunction in collegiate athletes

Because lumbopelvic–hip (LPH) dysfunction in athletes is commonly associated with subsequent low back pain (LBP), this cross-sectional derivation and internal validation study aimed to develop and internally validate a clinical triage scoring system (CTSS) for field-based identif...

Multimodal Graph Neural Networks and Evolutionary Knowledge Fusion for Secure and Explainable Governance in Intelligent IoT Interactive Media Systems

This research proposes a secure, explainable, and context-aware governance framework for blockchain-based digital media contracts in multimodal artificial intelligence–enabled AIoT interactive systems. As digital licensing, NFT copyright management, royalty distribution, and cros...

Development of the Screening Tool for Autism in Two-Year-Olds—Brief Form: Accuracy in Detecting Autism in Toddlers

Early diagnosis of autism is crucial for timely intervention, yet existing screening tools are often limited by administration time in clinical settings. This study developed and evaluated the Screening Tool for Autism in Two-Year-Olds—Brief Form (STAT-BF) for detecting autism in...

TargetPrior: A miRNA-Signature Embedded Evolutionary Learning Framework for Prioritizing Drug Targets in Acute Myeloid Leukemia

MOTIVATION: Prioritizing therapeutic targets from high-dimensional transcriptomic profiles is hindered by the underdetermined nature of the p ≫ n setting. While miRNA signatures can inform target prioritization, conventional accuracy-driven methods may yield unstable predictive s...

Particulate Matter-Induced Skin Injury: A Dual-Pathway AhR–Nrf2 Framework for Epidermal Homeostasis and Therapeutic Targeting

The aryl hydrocarbon receptor (AhR) is highly expressed in keratinocytes and functions as an environmental sensor regulating xenobiotic metabolism, epidermal differentiation, and inflammatory responses. Particulate matter (PM), a major environmental pollutant containing reactive...

Haptoglobin is associated with nocturnal blood pressure non-dipping in children with chronic kidney disease

Abstract Background Blood pressure (BP) follows a circadian rhythm that depends partly on endothelial nitric oxide (NO) bioavailability. Cell-free hemoglobin rapidly scavenges NO, and haptoglobin functions as a capacity-limited plasma buffer facilitating hemoglobin clearance. Whe...

Necrotising enterocolitis triggers a TNF-driven gut-blood-brain cascade that disrupts the blood-brain barrier and induces TNFR1-skewed neuronal apoptosis and pyroptosis

Necrotising enterocolitis (NEC) in very-low-birthweight (VLBW) infants is associated with neurodevelopmental difficulties, but the mechanisms linking intestinal disease to brain injury remain unclear. We asked whether NEC propagates along a tumour necrosis factor alpha (TNF-α)-ce...

Effects of Dynamic Neck Sensorimotor Biofeedback Training in Individuals With Mechanical Neck Pain: A Pilot Randomized Controlled Trial

Mechanical neck pain (MNP) is commonly accompanied by pain-related functional limitations, sensorimotor disturbances, and fear of movement, which together may contribute to persistent disability. This preliminary randomized controlled trial study investigated the short-term effec...

Smart Lithotripsy: Lasers, Energy Sources and Efficiency

PURPOSE OF REVIEW: To examine the evidence on contemporary lasers and provide a practical framework for platform selection, parameter optimization, and thermal safety based on the principles of smart lithotripsy. RECENT FINDINGS: Holmium: yttrium-aluminum-garnet (Ho:YAG) remains...

Diagnostic performance of a field-deployable iiPCR platform and viral load dynamics of MPXV Clade IIb in a cohort with high prevalence of HIV

BACKGROUND: Since 2022, the global outbreak of Mpox caused by the Mpox virus (MPXV) Clade IIb has underscored the need for timely and decentralized molecular diagnostics. Although quantitative real-time PCR (qPCR) remains the diagnostic gold standard, its infrastructure requireme...

Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan

Background Caring for people with both dementia and advanced care needs is complex. This study aimed to elucidate the prevalence of dementia and behavioral and psychological symptoms of dementia (BPSD) in patients receiving advanced care, including tube feeding, respiratory care,...