Kaohsiung Chang Gung Memorial Hospital

Short-film–based world café for faculty development in medical humanities: a mixed-method evaluation across three teaching hospitals

Clinical educators play a central role in guiding the professional identity formation, ethical reasoning, and communication skills of medical students. Rapid changes in healthcare, including evolving legal frameworks, increasing visibility of gender diversity, and the emphasis on...

A randomized pilot trial of non-flickering 40 Hz light stimulation: EEG activity and cognitive outcomes in cognitively normal older adults

Background Gamma-frequency (40 Hz) sensory stimulation is a promising non-pharmacological approach for modulating neural activity and cognitive function in aging and Alzheimer's disease. However, conventional flickering stimulation is often poorly tolerated, and evidence for non-...

Endometrial microbial culture in the era of mNGS: a prospective cohort study of endometrial dysbiosis in women with infertility

Endometrial dysbiosis (ED) and chronic endometritis (CE) have gained increasing attention as potential risk factors for implantation failure and infertility. However, their diagnostic assessment remains heterogeneous, and the clinical roles of microbial culture and metagenomic ne...

Beyond Weight Loss and Glycemic Control: Molecular Mechanisms and Hypothesis-Generating Therapeutic Potential of Incretin-Based Therapies Against Peritoneal Fibrosis in Peritoneal Dialysis

Background: Peritoneal dialysis (PD) is an established kidney replacement therapy, but long-term exposure to bioincompatible dialysate, uremic toxins, recurrent peritonitis, glucose degradation products, oxidative stress, and sterile inflammation progressively remodels the perito...

A hypothesis-driven perspective on GLP-1R-β-catenin pathway crosstalk in astrocyte plasticity and endogenous neural repair

Astrocytes exhibit pronounced, context-dependent plasticity following central nervous system (CNS) injury; however, their capacity for fate remodeling remains constrained by chromatin architecture, lineage-stabilizing signaling networks, inflammatory and metabolic states, and dis...

Single versus triple low-molecular-weight hyaluronic acid injection strategies with shockwave therapy for rotator cuff lesions: A randomized study with an exploratory historical comparator

Background Rotator cuff lesions without full-thickness tear commonly cause shoulder pain and functional limitation. Hyaluronic acid (HA) injections and extracorporeal shockwave therapy (ESWT) are widely used conservative treatments, but the optimal HA dosing strategy combined wit...

Combined Mesenchymal Stem Cells and Low-Energy Shock Wave Therapy Significantly Reduced Inflammation, Oxidative Stress and Preserved Podocytes in Diabetic Nephropathy

Diabetic nephropathy (DN) is among the leading microvascular complications of diabetes mellitus and a major cause of end-stage renal disease. Current treatments slow disease progression but do not restore lost podocytes. We tested whether Wharton’s jelly-derived mesenchymal stem...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Cryoablation versus thoracoscopic resection in the local management of pulmonary metastatic lesions: a single-center comparative study

Abstract Background Surgical resection remains a commonly used local treatment option for selected patients with pulmonary metastases. However, reoperation may be technically difficult after prior ipsilateral thoracic surgery or when substantial pleural adhesions are anticipated....

Machine Learning Model for Predicting Hepatocellular Carcinoma Development in Patients With Hepatitis B Virus‐Related Cirrhosis Receiving Antiviral Therapy

Few prediction models have been specifically designed to evaluate the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B and cirrhosis. This study aimed to develop a machine learning-based prediction model to assess the risk of developing HCC in patients...

Preoperative CT-measured lateral widening is an independent associated factor with CT-detected cruciate ligament avulsion in tibial plateau fractures

To identify radiographic and computed tomography (CT) parameters predictive of cruciate ligament avulsion fractures in patients with tibial plateau fractures (TPFs). We retrospectively analyzed 127 patients with TPFs, categorized by the presence ( n = 39) or absence ( n = 88) of...

Haptoglobin is associated with nocturnal blood pressure non-dipping in children with chronic kidney disease

Abstract Background Blood pressure (BP) follows a circadian rhythm that depends partly on endothelial nitric oxide (NO) bioavailability. Cell-free hemoglobin rapidly scavenges NO, and haptoglobin functions as a capacity-limited plasma buffer facilitating hemoglobin clearance. Whe...

Hip Arthroscopy–Assisted Management of Pipkin Types I and II Femoral Head Fracture–Dislocations: Mid‐Term Clinical and Radiographic Outcomes

OBJECTIVES: Hip arthroscopy-assisted surgery has been proposed as a minimally invasive option for femoral head fractures; however, evidence with mid-term follow-up remains limited. This study aimed to evaluate the clinical and radiographic outcomes of arthroscopy-assisted managem...

A Preliminary Evaluation of 177Lu-PSMA-617-Based Targeted Radioligand Therapy with X-Ray Stimulated PSMA Relocation Using the PiggyBac Reporter-Gene-Engineered Orthotopic Prostate Tumor Model

Background/Objectives: Because human prostate cancer (PCa) typically exhibits slow tumor growth, establishing reliable PCa tumor models is often time-consuming and unpredictable, thereby limiting the efficiency of preclinical theranostic research. To overcome this limitation, thi...

Prevention of new-onset chronic kidney disease with renin–angiotensin system blockers in type 2 diabetes with preserved kidney function

Renin–angiotensin system (RAS) blockers, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are known to slow chronic kidney disease (CKD) progression in patients with established renal impairment. However, whether RAS blockade ca...