Kansas City VA Medical Center

Claudin-2 protects from enteropathogenic E. coli-infection and colitis by promoting crypt fetalization via β1-integrin/FAK/YAP signaling

Abstract Citrobacter rodentium ( Cra ) infection, a murine model of enteropathogenic Escherichia coli (EPEC) infection, induces crypt proliferation that potentially promotes mucosal healing and pathogen clearance, yet the underlying molecular mechanisms remain poorly understood....

The COACH theory formalizes clinical reasoning in the development and validation of medical artificial intelligence systems

The development and deployment of medical artificial intelligence (AI) systems are limited by two persistent gaps: clinician knowledge is often introduced late in development as labels or annotations, and deployed systems often provide outputs that are difficult to reconcile with...