Kansai Medical University

Intraoperative detection of a false-negative facial motor evoked potential by direct facial nerve stimulation during vestibular schwannoma surgery: A case report

Background: False-negative transcranial facial motor evoked potential (FMEP) findings have previously been recognized retrospectively through discrepancies between preserved intraoperative FMEPs and postoperative facial palsy. To the best of our knowledge, no previous report has...

Olive Oil Before Oral Glucose Delays Gastric Emptying and Lowers Glycemia Through Partially Redundant Glucagon and GLP-1 Signaling in Mice

Consumption of fat before carbohydrate (preload) attenuates postprandial glucose excursions, although the underlying mechanisms remain unclear. We investigated whether an olive oil preload (OG) reduces glycemia by engaging endocrine and neural regulation of gastric emptying. Wild...

Renal function–adjusted initial JAK inhibitor dosing and outcomes in rheumatoid arthritis: from the ANSWER cohort study

INTRODUCTION/OBJECTIVES: To evaluate clinical effectiveness and treatment persistence after renal function-guided reduced-dose initiation of Janus kinase inhibitors (JAKis) in rheumatoid arthritis (RA). METHOD: We analysed 368 adults initiating a JAKi in the ANSWER registry (2013...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

Antidepressants and breast cancer risk: a meta-analysis of exposure windows and cumulative use in nearly two million women

Abstract Background The use of antidepressants is steadily increasing worldwide. This trend has a significant impact on public health and socioeconomic conditions. Although studies have looked for a possible link between antidepressants and breast cancer risk, findings remain unp...

Primary Cerebral Pleomorphic‐Myxoid Sarcoma With Many Hyaline Globules

ABSTRACT A case of primary sarcoma that arose in the right temporal lobe of a 59‐year‐old man is reported. The patient had a history of resection of a “pituitary tumor” and postoperative radiotherapy about 40 years earlier. The cerebral tumor consisted of loose and diffuse prolif...

Comparative effectiveness of three treatment strategies for submacular hemorrhage secondary to age-related macular degeneration

Abstract We aimed to compare the effectiveness of three treatment strategies for extensive submacular hemorrhage (SMH) secondary to age-related macular degeneration (AMD): intravitreal anti-vascular endothelial growth factor (VEGF) monotherapy, anti-VEGF combined with sulfur hexa...

Epidemiology of macular dystrophy in Japan (2011–2020): a nationwide population-based study

Abstract Purpose To describe the characteristics and prevalence of macular dystrophy using a comprehensive national claims database in Japan. Study design Population-based retrospective study using a nationwide claims database. Methods Approximately 126 million individuals covere...

Cytokine upregulation and ocular surface dysbiosis in lacrimal drainage pathway disease and its associated keratopathy: a prospective multicenter observational study

Abstract Background To elucidate the pathogenesis of lacrimal drainage pathway disease-associated keratopathy (LDAK), we investigated the cytokine profile in tear fluid and the ocular surface microbiome in patients with lacrimal duct disorders. Methods This multi-center prospecti...

Baseline Eating Behaviors and Responsiveness to TelePhysio in Older Patients with Type 2 Diabetes: An Exploratory Secondary Analysis of the TelePhysioT2D Trial

Background/Objectives: Telerehabilitation for physiotherapy programs (TelePhysio) has been shown to improve knee extension force (KEF) in older patients with type 2 diabetes mellitus (T2DM), but factors associated with responsiveness remain unclear. This exploratory secondary ana...

Efficacy and Safety of Stereotactic Body Radiation Therapy for Metastatic Bone Tumors in Clinical Practice

Abstract Background: The development of radiation techniques has demonstrated that stereotactic body radiation therapy (SBRT) effectively achieves good local control and long-term pain palliation for metastatic bone tumors. This study evaluated the efficacy and safety of SBRT for...

Real-world Feasibility of Adjuvant Nivolumab for High-risk Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy

Background/Aim: Adjuvant nivolumab is an important postoperative option for high-risk muscle-invasive urothelial carcinoma, but upper tract urothelial carcinoma (UTUC)-specific real-world evidence remains limited. This study evaluated oncologic outcomes, feasibility, and safety o...

Indoleamine 2,3‐Dioxygenase 1 as an Adjunctive Histopathological Marker of Cholangitis Activity in Primary Biliary Cholangitis

ABSTRACT Aim To investigate the expression and clinicopathological significance of indoleamine 2,3‐dioxygenase 1 (IDO‐1) in primary biliary cholangitis (PBC), particularly its potential role as an adjunctive histopathological marker for diagnosis in early or atypical cases and as...