Kanazawa Medical University

Towards responsible AI in workplace-based assessment: a scoping review using Downing’s framework

This scoping review maps generative AI applications in workplace-based assessment (WBA) and analyzes validity evidence through Downing’s framework. Following JBI methodology and PRISMA-ScR guidelines, four databases were searched (2022-February 2026) with dual-AI screening and hu...

Relationship between objective sleep efficiency and psychological distress in middle-aged and older Japanese: Results by work in the Shika study

Sleep quality and work, as factors related to psychological distress, have not yet been elucidated. Additionally, few studies have examined the association between sleep efficiency and psychological distress, which may affect psychological distress in middle-aged and older adults...

Multimodal Deep Learning with Automated Myocardial Segmentation for Classification of Myocardial 99mTc-Pyrophosphate Uptake Using Planar and SPECT Imaging

Objective interpretation of myocardial 99mTc-pyrophosphate (PYP) uptake is important in suspected cardiac amyloidosis. We developed a segmentation-informed multimodal framework that classifies myocardial PYP uptake from planar and single-photon emission computed tomography (SPECT...

Single‐Vesicle Functional Nanophenotyping Reveals Heterogeneous PD‐L1 Accessibility in Triple‐Negative Breast Cancer

The functional accessibility of membrane proteins is a fundamental determinant of biological activity but cannot be accurately inferred from protein abundance alone. Current extracellular vesicle (EV) analyses primarily quantify expression levels, providing limited information on...

Dual Aberrant Splicing Caused by an Apparently Missense CHD7 Variant, c.5273A>G ( p.Asp1758Gly ), in CHARGE Syndrome

ABSTRACT CHARGE syndrome is a rare congenital disorder primarily attributed to heterozygous pathogenic variants of the CHD7 gene. Most pathogenic CHD7 variants are loss‐of‐function (LoF) variants, whereas the interpretation of missense variants remains challenging in the absence...

Demographic and clinical characteristics of rapidly progressive glomerulonephritis in renal vasculitis in the Japan renal biopsy registry

This study evaluated the clinical and demographic characteristics of biopsy-proven rapidly progressive glomerulonephritis (RPGN), with histological evidence of renal vasculitis. We focused on five vasculitis-related nephritides: MPO-ANCA, PR3-ANCA, anti-GBM, IgA vasculitis (IgAV)...

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...

Translation and Validation of the Japanese Version of the Dialysis Patient‐Perceived Exercise Benefits and Barriers Scale

BACKGROUND: Regular exercise is recommended for patients undergoing haemodialysis; however, participation rates remain low in Japan. Perceived benefits and barriers are key cognitive determinants of exercise behaviour, yet no validated instrument exists to assess these perception...