Kanagawa Prefectural Hospital Organization

Preoperative prognostic stratification of high-risk resectable pancreatic cancer: combined Podxl/itgb1 expression in EUS-FNAB specimens as a prognostic biomarker

Neoadjuvant chemotherapy with gemcitabine and S-1 (NAC-GS) is a conditionally recommended treatment for resectable pancreatic ductal adenocarcinoma (PDAC) in Japan. However, therapeutic efficacy remains limited in a subset of patients who lose surgical opportunities due to tumor...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

Cold Resection for Superficial Non‐Ampullary Duodenal Epithelial Tumors: Current Evidence and Clinical Perspectives

ABSTRACT Superficial non‐ampullary duodenal epithelial tumors (SNADETs) are increasingly treated with endoscopic resection. Although conventional thermal techniques are effective, the thin duodenal wall and distinctive anatomy have driven interest in cold resection techniques tha...

Feasibility and effects of a multicomponent program incorporating esports on physical and cognitive function among older adults: A non-randomised pilot trial

Background Esports (competitive and organised video gaming) may enhance physical and cognitive health in older adults. The aim of this study was to examine the feasibility and effects of a multicomponent program incorporating esports on physical and cognitive function in communit...

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (m...

P1.249. Thoracoscopic Esophagectomy With Superior Mediatinal Lymphadenectomy Usiing Intraoperative Nerve Monitoring to Avoid Postoperative Recurrent Laryngeal Nerve Palsy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Esophageal cancer frequently metastasizes to superior mediastinal lymph, necessitating thorough lymphadenectomy. However, the Japanese National Cancer Database reports significantly h...

Lactate dehydrogenase-to-lymphocyte ratio predicts overall and progression-free survival among patients with advanced small-cell lung cancer receiving first-line chemoimmunotherapy

Platinum plus etoposide combined with programmed death-ligand 1 (PD-L1) inhibitors is the standard first-line therapy for patients with advanced small-cell lung cancer (SCLC). However, reliable prognostic biomarkers are yet to be identified. The lactate dehydrogenase-to-lymphocyt...