Kaiser Permanente South San Francisco Medical Center

Intranigral injection of alpha-synuclein pre-formed fibrils leads to BBB compromise and bilateral dopaminergic neurodegeneration in A53T alpha-synuclein transgenic mice

ABSTRACT Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by alpha-(α)-Synuclein neuronal aggregation and loss of dopaminergic (DA) neurons. Developing animal models that replicate PD’s neuropathological phenotypes is critical for understanding i...