Kaiser Permanente San Francisco Medical Center

Developing a drug-level feedback adherence counseling intervention for young MSM in the U.S.

Background: Young men who have sex with men (MSM) in the U.S. have suboptimal adherence to oral tenofovir-based pre-exposure prophylaxis (PrEP), undermining HIV prevention goals. Drug-level feedback using urine point-of-care tenofovir assays has improved adherence in Eastern and...

Development and Validation of a Coronary Artery Calcium Volume and Density Score

BACKGROUND: Coronary artery calcium (CAC) scoring is a useful tool for coronary heart disease (CHD) risk prediction. The current standard method, the Agatston score, weights plaque area upward by density. However, higher density is inversely associated with CHD. We aimed to devel...

2025 AHA/ACC blood pressure guideline and HEARTS 2.0: implications for the future evolution of integrated cardiovascular–kidney–metabolic care in the Americas

ABSTRACT Hypertension is the leading modifiable risk factor for cardiovascular disease. In 2025, two major evidence-based frameworks evolved in parallel: HEARTS 2.0, an implementation-oriented clinical pathway for integrated cardiovascular–kidney–metabolic (CKM) care through prim...

Get With The Guidelines–Heart Failure Hospital Participation and Its Association With Guideline-Directed Medical Therapy and Outcomes

Abstract Purpose Despite strong evidence, real-world adoption of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) remains suboptimal. The Get With The Guidelines–Heart Failure (GWTG-HF) program was designed to close gaps in care....

Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence

Importance Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems routinely use outreach to promote preventive care, most strategies are static and lack evidence from randomized clinical trials. Objective To determine wh...

Modernizing the Institutional Review Board Process for Implementation Science – A Narrative Review of Barriers and Ethical Considerations

Abstract Purpose of Review This review highlights the barriers and facilitators that implementation science studies face in the institutional review board (IRB) approval pathway and provides recommendations on how to potentially streamline this process. Recent findings Significan...

Web Monitoring as an Early Warning System: “Benadryl Challenge” Online Mentions Correlate With Diphenhydramine Overdoses Reported to US Poison Centers

PURPOSE: Social media has propagated several "challenges" that engage primarily adolescents in life-threatening behaviors such as the "Benadryl Challenge," where participants film themselves ingesting large doses of diphenhydramine. Once shared online, these activities have the p...

Impact of alcohol use discontinuation on adipose tissue insulin resistance among Latino patients with and without underlying chronic liver disease

Abstract We evaluated the effect of short-term moderate alcohol discontinuation on adipose tissue insulin resistance (adipo-IR) and factors associated with its change in Latinos with and without hepatitis C virus (HCV). Nondiabetic Latino adults without (N = 17) or with (N = 7) H...