Kaiser Permanente Bernard J. Tyson School of Medicine

Mental Health Factors in Cardiothoracic Surgery Risk Prediction Models: A Systematic Review

BACKGROUND: Mental health disorders are associated with substantial morbidity and death in cardiovascular disease, yet their role in perioperative risk stratification remains unclear in patients undergoing cardiothoracic surgery. We evaluated how mental health disorders are curre...

Patient Characteristics and Outcomes Associated With Home‐Based Cardiac Rehabilitation

Background Referrals to and participation in cardiac rehabilitation programs remain suboptimal. We examined factors associated with home‐based cardiac rehabilitation (HBCR) referral and participation and associations of referral and participation with outcomes. Methods In this re...

A rapid, inexpensive diagnostic for bacterial pathogen and resistance detection in resource-limited settings

Antimicrobial resistance is a major global health threat, with disproportionate impact in regions with limited diagnostic infrastructure. To address this challenge, we developed BADLOCK (Bacterial and AMR Detection by SHERLOCK), a rapid, low-cost molecular diagnostic platform for...

Trends in annual medication possession in older adults with type 2 diabetes

BACKGROUND: Older adults (≥65 years) make up a substantial portion of individuals with type 2 diabetes (T2D) and frequently experience multimorbidity requiring complex, costly medication regimens. Cost-related nonadherence is prevalent in this population because of fixed incomes,...

Brain Penetrant Calcium Channel Blockers Were Not Associated With Reduced Alcohol Consumption: Converging Results From Two Large Independent Cohort Studies Using Electronic Health Records

ABSTRACT Purpose Alcohol use disorder (AUD) remains a major public health problem, with few effective treatments. L‐type calcium channel blockers (LTCCBs) have genetic and preclinical support as potential treatments for AUD. Methods We evaluated whether brain penetrant (BP)‐LTCCB...

2025 AHA/ACC blood pressure guideline and HEARTS 2.0: implications for the future evolution of integrated cardiovascular–kidney–metabolic care in the Americas

ABSTRACT Hypertension is the leading modifiable risk factor for cardiovascular disease. In 2025, two major evidence-based frameworks evolved in parallel: HEARTS 2.0, an implementation-oriented clinical pathway for integrated cardiovascular–kidney–metabolic (CKM) care through prim...

Virtual parenting intervention to promote positive parenting and prevent child anxiety and depression symptoms among filipino americanfamilies: protocol for a randomized controlled trial

Filipino youth in the U.S. experience higher rates of depression, suicidal ideation, anxiety, and substance use when compared to other Asian subgroups and non-Hispanic whites, yet are less likely to seek help or receive preventive care. Evidence-based parenting interventions have...

Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence

Importance Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems routinely use outreach to promote preventive care, most strategies are static and lack evidence from randomized clinical trials. Objective To determine wh...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...