Kai Biotech (South Korea)

Genetic principles enabling the creation of bacteria-based therapeutics

Abstract Genetic engineering can transform bacteria (including Salmonella, Escherichia coli, Listeria, and Yersinia) from naturally occurring microbes into programmable therapeutics. Unlike passive platforms, engineered bacteria can localize to defined biological niches, sense en...

ALOX15-Inhibitory Peptides Derived from Coffee Bean Protein Hydrolysates Confer Neuroprotection against Lipid Peroxidation

Abstract Coffee beans are widely consumed worldwide and are known for their central nervous system-stimulating effects, mainly attributed to caffeine and other small molecules. However, the neuroprotective potential of coffee bean-derived peptides remains largely unexplored. In t...

Anti-inflammatory effects and attenuation of alveolar bone loss potential of honeysuckle-derived nanovesicles (HELNs) in periodontitis treatment

Periodontitis is a common chronic inflammatory disease primarily caused by the accumulation of dental plaque and host immune responses. If left untreated, it can lead to alveolar bone resorption and tooth loss. Existing treatments such as antibiotics and surgical interventions ha...

Salt-tolerant β-glucosidases from Karamay saline soil for soybean isoflavone bioconversion

β-Glucosidase (EC 3.2.1.21) hydrolyzes β-glycosidic bonds and is widely used in the food, fuel, and pharmaceutical industries. It holds significant potential particularly for converting glycosides, such as soybean isoflavone glycosides and ginsenosides, into their more bioactive...