Kagawa University

Current Trends in the Novel Serological Protein and Blood-Based Biomarkers for Early Detection and Prognostic Prediction of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. HCC largely develops in patients with chronic liver diseases, including chronic hepatitis and liver cirrhosis. The surveillance in such patients is extremely important for the detection of HCC as...

Biophysical and structural characterisation of a quasi-stable toxic dimer of amyloid Aβ42 peptide tethered at position 34

Abstract Non-fibrillar oligomeric forms of amyloid β (Aβ) mediate toxicity in Alzheimer’s disease (AD) with Aβ accumulation preceding tau aggregation and synaptic damage. Aβ oligomerization is thought to initiate from the smallest stable unit, the dimer, yet structural details of...

Targeting Glucose Metabolism in Bladder Cancer: Therapeutic Implications of 2-Deoxy-D-glucose

Bladder cancer is characterized by metabolic reprogramming, and enhanced glycolysis contributes to tumor progression and therapeutic resistance. Because the anticancer activity of 2-deoxy-D-glucose (2-DG) has been reported in several malignancies, this study evaluated the antipro...

The Clinical Characteristics and Management of Dental-Related Foreign Body Accidents: A Retrospective Observational Study

Background: Dental-related foreign body accidents are uncommon but potentially serious iatrogenic complications. Although numerous case reports have been published, comprehensive clinical studies describing their clinical characteristics, management, and outcomes remain limited....

Association Between Early Perioperative Fentanyl Exposure and Dose-Normalized Tacrolimus Exposure After Kidney Transplantation

Introduction Tacrolimus exposure varies early after kidney transplantation, and perioperative factors may complicate therapeutic drug monitoring. Fentanyl is commonly used perioperatively, but its association with dose-normalized tacrolimus exposure is unclear. Project Aims or Qu...

Clinical Significance of a Cell‐Of‐Origin‐Based Classification in Pancreatic Ductal Adenocarcinoma

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited therapeutic options and poor clinical outcomes. Although PDAC has traditionally been thought to arise from ductal epithelial cells, recent studies using genetically engineer...

Structure-oriented deep learning for semantic segmentation of bridge point clouds

Bridges built during the post-war construction boom are reaching the end of their design life, and their inspection still relies mainly on manual visual assessment. The specific question addressed is whether bridge components can be segmented accurately and efficiently from raw p...

Seasonal variations and controlling factors of nitrogen fluxes at the sediment-water interface in a semi-enclosed inland sea

Abstract. Nitrogen fluxes across the sediment-water interface and nitrogen removal from sediments are essential components of nitrogen cycle in semi-enclosed inland seas. However, the difficulty in observational sampling hinders continuous data availability that is necessary to u...

Decoupling skeleton stability and water dynamics in C–S–H by in situ SAXS and H2O/D2O-atmosphere SANS

Humidity-induced microstructural changes in calcium silicate hydrate (C–S–H) have been widely studied by small-angle X-ray scattering (SAXS) and proton nuclear magnetic resonance (1H NMR) relaxometry; yet neither technique has been able to separate the contributions of the Ca–Si...

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (m...

Spontaneous segmentation of slow slip events on a homogeneous planar fault

Abstract Slow slip events (SSEs) are transient aseismic fault slip events that often display segmentation along strike. While fault segmentation is commonly attributed to physical heterogeneities, numerical studies have shown that segmentation can also occur on homogeneous planar...

The twofold cost of sex reconsidered: Meiotic mechanisms protect anisogamous populations from invasion by thelytoky

Most multicellular animals practice anisogamy (fertilization between eggs and sperm). When mothers produce sons and daughters at a 1:1 ratio, the "twofold cost of males" arises because males do not directly contribute to population growth. If thelytokous parthenogens producing on...

Gut microbial and metabolic biomarkers for early-onset colorectal cancer

Early-onset colorectal cancer (EO-CRC) is a growing global health challenge with poorly understood etiology. While gut microbiota and metabolites are implicated in colorectal carcinogenesis, EO-CRC-associated signatures remain poorly characterized. This study presents the first l...