Juntendo University Urayasu Hospital

Fatal Dilated Cardiomyopathy and Monogenic Diabetes Mellitus as SMPD4 ‐Related Disorder

ABSTRACT Sphingomyelin phosphodiesterase 4 (SMPD4)‐related disorder is a rare neurodevelopmental disorder caused by biallelic loss‐of‐function variants in SMPD4, characterized primarily by severe neurological manifestations. A subset of long‐term survivors develops diabetes melli...

Effects of residency matching policies on regional distribution of residents: a simulation study using a stable matching algorithm

Abstract Background Appropriate geographical allocation of medical residents is often proposed to alleviate the regional maldistribution of physicians in Japan; however, its effectiveness remains unclear. We assessed the impact of adjusting residency positions and evaluated the e...

Total Synthesis of the Antifungal Clinical Candidate ASP2397 Cyclohexapeptide Facilitated by the Chemo-selective Reduction of Secondary N -Benzyloxyamides

Abstract ASP2397 is a siderophore-like cyclic hexapeptide with potent and rapid fungicidal activity against Aspergillus species. We report here its first total synthesis, enabled by an unprecedented one-pot chemoselective reduction of secondary N-benzyloxyamides that strictly pre...

Leveraging the salivary microbiome profile to stratify REM sleep behavior disorder and synucleinopathies

Abstract Few studies have explored noninvasive biomarkers of synucleinopathies, including Parkinson’s disease (PD), and rapid-eye-movement behavior disorder (RBD), a prodromal stage for these conditions. Human oral/salivary microbiomes are altered in PD, highlighting their potent...

Successful Use of the Nausicaa Compression Suture in a Case of Placenta Accreta Spectrum

Successful use of the Nausicaa compression suture in a case of placenta accreta spectrumAuthorNaoko Suga, Shintaro Makino, Ayumi Yasuda, Takahumi UjihiraAffiliationDepartment of Obstetrics and Gynecology, Juntendo University Urayasu Hospital, Chiba, JapanCorrespondenceShintaro Ma...

Hepatoprotective Effects of Imeglimin Are Associated With Preserved Mitochondrial Bioenergetics and Reduced Oxidative Stress in a Murine Cholestasis Model

PURPOSE: Biliary atresia is a cholestatic liver disease that causes persistent inflammation and reduces the hepatic reserve. New therapeutic concepts are crucial to improve native liver survival. We investigated whether imeglimin, a mitochondria-targeting agent, has hepatoprotect...