JSS Academy of Higher Education and Research

Rationally Designed Phenyl- and Phenanthryl-Based Imidazole Hybrids for the Treatment of Breast Cancer—A Structure–Activity Relationship Study

A series of 11 compounds of phenyl–imidazole–pyrrole and 9 compounds of phenanthryl–imidazole–pyrrole were synthesized and evaluated against breast cancer cell lines differing in the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth facto...

Consensus-informed design of digital case-based learning for clinical and public health reasoning in undergraduate Community Medicine: a modified Delphi study

Community Medicine requires undergraduate medical students to integrate clinical reasoning with epidemiological interpretation, the social determinants of health, national health-programme linkage and preventive decision-making. Digital case-based learning (DCBL) may support this...

Silencing with precision: In silico strategies for antisense oligonucleotide engineering

Therapeutics based on nucleic acids are emerging as a transformative drug class in the era of personalized medicine. They include antisense oligonucleotides (ASOs), aptamers, small interfering RNAs (siRNAs), small activating RNAs (saRNAs), microRNAs (miRNAs), and long non-coding...

Pattern of analgesic use among adults in Mysuru, Karnataka: a community-based cross-sectional survey

Abstract Background Pain is among the most prevalent health complaints globally, and analgesics rank among the most frequently consumed medications in community settings. Self-medication with analgesics is a recognised public health concern in India, yet community-level data from...

A cross-sectional study on sleep quality and its determinants among adults in an urban community of Mysuru

Sleep is an essential pillar of lifestyle medicine and plays a crucial role in maintaining physical, mental, and emotional health. Digital exposure and changing lifestyles are increasingly disrupting sleep among adults, resulting in adverse health outcomes. The objective of the s...

Hybrid endoscopic submucosal dissection enhances efficiency with comparable curative outcomes: a Bayesian meta-analysis, systematic review, and Monte Carlo simulation of randomized controlled trials

Background/Aims: Gastrointestinal (GI) cancers accounted for 3.24 million deaths worldwide in 2022. Endoscopic submucosal dissection (ESD) enables en bloc resection of early neoplasms but is time-intensive and technically challenging. Hybrid ESD (H-ESD), which combines dissection...

Utilization, Accessibility and Outcomes of Parent-Mediated Therapies for Neurodivergent Children in India: A Systematic Review

The Neurodevelopmental Disorders (NDDs) data on evidence-based interventions is significantly underrepresented in India, which is mainly due to the lack of specialists and a significant geographic barrier to care. This systematic review is a critique of the effectiveness, accessi...

A systematic review of geospatial techniques for ecological vulnerability modelling across ecological domains

Vulnerability modelling in ecology is increasingly studied within the framework of vulnerability assessment, measurement, and modelling, as well as adaptation and security. Geospatial technology plays a very significant role in ecological studies and in assessing the sensitivity...

Tuberous sclerosis in a young child: A case report

Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterised by dysregulation of the mammalian target of rapamycin (mTOR) pathway, leading to hamartoma formation in multiple organs. Early neurological manifestations, particularly seizures, are common but may p...

Green AQbD-based HPLC method for estimation of isosorbide dinitrate in bulk and wafers

Isosorbide dinitrate (ISDN) is widely used in the management of cardiovascular disorders; however, conventional analytical methods often rely on extensive organic solvent consumption and lack systematic optimization, raising concerns regarding environmental sustainability and met...

Small Airway Dysfunction Affects One in Five Indian Adolescents: The Multicity APEAL Study

Summary Small airway dysfunction affected one in five adolescents and varied substantially across four Indian cities. Age, sex and study city, but not ambient PM 2.5 or NO 2 , were independently associated with FEF 25–75 .

Prediction of cardiovascular disease by using a genetic algorithm over a stacked ensemble model

A two-layer customized ensemble model is suggested in this work to improve the prediction accuracy of cardiovascular disease. Two ensemble classifiers are stacked as part of the model architecture. While Support Vector Machine (SVM) and Decision Tree (DT) are used as base learner...

Hydrothermally synthesized Dy³⁺ doped SrZrO₃ nanophosphors for efficient white light emission and latent fingerprint detection

Environmental safety and energy conservation have emerged as the two most crucial fields in the past few years. This paper reports, the simple hydrothermal approach used to prepare Dy 3 + ions (1–9 mol%) incorporated SrZrO 3 nanopowders (NPs). A thorough investigation was conduct...

7-Deshydroxypyrogallin-4-carboxylic acid dietary phytochemical as a putative FTO inhibitor in breast cancer: an integrated computational and cytotoxicity study

Abstract Breast cancer is the most frequently diagnosed malignancy in women globally, representing a major global health burden, with a significant subset of cases exhibiting resistance to standard therapeutic regimens. Recently, m 6 A RNA demethylases such as FTO have been ident...

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft

BACKGROUND: KRAS G12C-mutant advanced non-small cell lung cancer (NSCLC) is currently treated with KRAS G12C covalent inhibitors, such as sotorasib, or RAS (ON) G12-selective inhibitors; however, response rates and progression-free survival remain limited, with recurrence occurri...

Death-Associated Protein Kinase 1 (DAPK1) Signalling at the Crossroads of Apoptosis, Autophagy, and Post-transcriptional Cascades in Neurodegenerative Diseases

Death-associated Protein Kinase-1 is a Ca2+/calmodulin- dependent serine/threonine protein kinase which controls various cellular processes and functions, including apoptosis, autophagy, and post-transcriptional processes, through multiple microRNAs. Increasing evidence suggests...

A narrative review of determinants consequences, and public health implications of vaccine hesitancy in Nigeria

Vaccine hesitancy remains a significant barrier to achieving optimal immunisation coverage in Nigeria, contributing to recurrent outbreaks of vaccine-preventable diseases and limiting progress towards national and global public health goals. This narrative review synthesises rece...

Assessment of drought hazard change across agro-climatic regions of India under 2 °C, 3 °C and 4 °C warming levels based on CMIP6 projections

Abstract Background Over half of India’s agricultural land relies on rainfall, and changes in drought frequency, duration, and intensity directly impact agricultural productivity and water resources. However, comprehensive evaluations of composite drought hazards across the natio...

Nutritional insights in endodontics: a review of micronutrients in root canal therapy

Purpose: Micronutrients play critical and multifaceted roles in the biological processes governing endodontic healing. This review aimed to evaluate the therapeutic roles of essential micronutrients, including vitamin D, vitamin C, calcium, zinc, magnesium, and selenium, in modul...