Jordan Valley Semiconductors (China)

Multikilogram-Scale Process Development for a Key Intermediate of a Clinical-Stage MTA-Cooperative PRMT5 Inhibitor

Abstract A multikilogram-scale, scalable, and cGMP-compliant synthesis of 4-aminoimidazo[1,5-a]quinoxaline-8-carboxylic acid (TM), a key intermediate for the MTA-cooperative PRMT5 inhibitor GTA182, has been developed to address the limitations of the original medicinal chemistry...

Study on the Accumulation, Excretion, and Distribution of Cadmium in Mice After Dietary Exposure to Cadmium-Rich Swimming Crab Portunus trituberculatus

To investigate the patterns of cadmium accumulation and distribution in mice following oral ingestion of cadmium-enriched Portunus trituberculatus, this study selected 4-week-old ICR mice as a model organism. A control group was fed a standard diet, while an exposure group was fe...