Johnson & Johnson (United States)

Patient perspectives from the BEYOND Delphi panel: burden of remaining symptoms and their fluctuations, despite treatment, in patients with generalised myasthenia gravis

Abstract Background Patients with generalised myasthenia gravis (gMG) can experience remaining symptoms despite treatment. Our study aimed to describe how remaining symptoms and their fluctuations may affect a person’s daily life while living with gMG. Methods A modified-Delphi p...

Robust out-of-distribution prediction of Buchwald–Hartwig reactions

Abstract The Buchwald–Hartwig cross-coupling is a cornerstone of modern pharmaceutical synthesis, yet predictive modeling of its outcomes remains constrained by data quality and chemical space coverage. Electronic laboratory notebooks contain heterogeneous, noisy records, while o...

Hindlimb and pelvic girdle reduction with associated skeletal changes in the South African limb-reduced skink Scelotes Fitzinger, 1826

We used stained specimens to describe hindlimb and pelvic girdle reduction in a skeletal morphocline of Scelotes species, a South African scincine group, as well as how the two processes are interrelated. The findings reflect the generally varied nature of the evolutionary pathwa...

Expedited research and approval of medicines for drug-resistant bacterial infections in children.

Multidrug-resistant pathogens cause severe infections with substantial morbidity and mortality in neonates, infants and children, as they do in adults. However, the approval of therapies for multidrug-resistant infections in paediatric patients often lags years behind approval fo...