Johnson & Johnson (Netherlands)

Understanding the Lived Experience of Fetal and Neonatal Alloimmune Thrombocytopenia: A Qualitative Study

Objective Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare alloimmune disease of pregnancy. This study aimed to better understand the disease burden of FNAIT and its impact on families through qualitative research. Study Design This exploratory, qualitative study...

Rationally designed FimH variants with enhanced functional immunogenicity as vaccine candidates for ExPEC urinary tract infections

Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) is a major cause of urinary tract infections (UTIs) and invasive disease. Rising antimicrobial resistance highlights the need for preventive strategies such as vaccination. The conserved D-mannose-specific adhesin FimH...

Patient perspectives from the BEYOND Delphi panel: burden of remaining symptoms and their fluctuations, despite treatment, in patients with generalised myasthenia gravis

Abstract Background Patients with generalised myasthenia gravis (gMG) can experience remaining symptoms despite treatment. Our study aimed to describe how remaining symptoms and their fluctuations may affect a person’s daily life while living with gMG. Methods A modified-Delphi p...

Immune correlates of protection against RSV following Ad26.RSV.preF–RSV preF vaccination of adults aged >60 years

Abstract Respiratory syncytial virus (RSV) is a leading cause of respiratory illness and there is no universally accepted serological correlate of protection (CoP). We evaluated serum pre-fusion immunoglobulin G binding (preF-IgG) and RSV-A2 neutralizing antibodies (RSV-nAb) in a...