Johns Hopkins Hospital

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

Mistreatment during facility-based childbirth in Benin City, Nigeria: A convergent mixed-methods study of prevalence and drivers

Abstract Background Mistreatment during facility-based childbirth undermines maternal health outcomes and trust in health systems, particularly in low- and middle-income countries. Nigeria bears one of the highest global burdens of maternal mortality, yet limited large-scale mixe...

Availability and Quality of Electronic Health Record Data to Track Physical Function Across a Care Transition

ABSTRACT Introduction Physical function (PF) is critical to quality of life and healthcare value, especially for older adults following hospitalization. Monitoring PF supports recovery, reduces adverse events, and improves care transitions. Despite the potential of electronic hea...