John Paul II Hospital

Nerve anastomoses in the upper limb: an up-to-date meta-analysis

Introduction There are numerous communicating branches (CB) between the nerves of the brachial plexus. Therefore, the objective of this study was to provide comprehensive data on the prevalence, morphometry, and anatomical classifications of upper extremity anastomoses such as: M...

The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry

Abstract Aims The right ventricle (RV) is a major determinant of outcome in pulmonary arterial hypertension (PAH), but its assessment has not been completely incorporated in the risk of mortality scores. We therefore evaluated the added value of echocardiography of the RV to risk...

Red blood cell‐directed immune responses in COVID ‐19: Mechanisms, clinical evidence and implications for transfusion medicine

Abstract SARS‐CoV‐2 infection is associated with a broad spectrum of red blood cell (RBC)‐directed immune responses, ranging from isolated direct antiglobulin test (DAT) positivity to autoimmune hemolytic anemia (AIHA) and transfusion‐related diagnostic challenges. This narrative...

Clinical characteristics associated with failure to achieve a prespecified guideline-directed medical therapy target at discharge in patients with HFrEF undergoing scheduled hospitalization: a secondary analysis of the HEROES study

Abstract Guideline-directed medical therapy (GDMT) is crucial for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). The aim of the study was to identify clinical characteristics associated with failure to achieve the prespecified stringe...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Robot-assisted urologic surgery after kidney transplantation: indications, graft-protection strategies, and outcomes—a scoping review

Kidney transplantation relocates a vascularized graft and ureter into the iliac fossa, changing subsequent urologic surgery. Existing syntheses are procedure-specific. This scoping review mapped indications, graft-protection strategies, outcomes, and evidence gaps across robot-as...

Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications

Placebo and nocebo effects on pain provide a model for investigating how cognitive and contextual factors modulate the physiological processes underlying nociception and its regulation. However, existing accounts remain fragmented and lack a unifying mechanistic framework linking...