Johannes Kepler University of Linz

Association between adherence patterns to antifibrotic therapy and survival in fibrotic interstitial lung disease: a nationwide Austrian health claims study

Antifibrotic therapies slow disease progression in patients with progressive fibrosing interstitial lung diseases (PF-ILD). However, long-term adherence is difficult to maintain mainly due to side effects. Real-world data on adherence and its association with prognosis are still...

Environmental sustainability management in social service nonprofits: insights into drivers, challenges and opportunities

Purpose Social service nonprofit organizations (SocS-NPOs) have evolved to adopt an entrepreneurial mindset, while also fulfilling their social missions. Balancing different institutional logics, like in their case the business, social-welfare and government logic, is challenging...

Screening for amyloidosis in trigger finger release and Dupuytren’s fasciectomy

INTRODUCTION: This study investigated the prevalence of amyloid deposition in tissue obtained during trigger finger release and limited fasciectomy for Dupuytren's disease and whether these procedures may allow early detection of cardiac amyloidosis. METHODS: This prospective, ex...

High-fidelity animal model simulation improves surgical competence in medical students

To determine whether a formal suturing simulation course using a realistic animal model improves medical students’ perception of their technical competence and their later self-confidence in a competency-based model of surgical education. The opportunities to acquire hands-on tra...

Idylla™ POLE-POLD1 mutation assay for molecular characterization and risk stratification of endometrial cancers: a retrospective multicenter validation study

Endometrial carcinoma (EC) is a common gynecological cancer with rising incidence driven by obesity and aging populations. Accurate and timely molecular classification is critical for guiding personalized oncology treatment, especially in early-stage high-grade endometrioid carci...

Nutritional intake and growth in very low birth weight infants: a comparison of standardized versus parent-led complementary feeding

Abstract The complementary feeding (CF) period is critical for ensuring adequate nutrient intake to support optimal growth in very low birth weight (VLBW) infants. This analysis compares nutritional intake and growth across two CF strategies: a standardized, protocol-driven appro...

Hand hygiene versus continued glove use in simulated nursing care: a crossover study on microbial kinetics and unintended transmission

Healthcare workers’ (HCWs) hands are primary vectors for pathogen transmission. While non-sterile examination gloves (NSG) are intended to protect against contamination, they are often perceived as a substitute for hand disinfection (HD). This crossover simulation study in studen...

NEW INC Y12 Creative Science: A Longitudinal Art–Science Study of the Microbiota–Gut–Brain Axis

RationaleDespite growing recognition that emotion is shaped by the whole body, research models have remained largely brain-centric, overlooking microbial and biochemical systems in the gut.The microbiota-gut-brain axis (MGBA) represents one such underexplored layer: gut microbes...

DNA methylation of silencer-annotated regions at the MGMT locus in the context of promoter and enhancer methylation in glioblastoma and melanoma brain metastases

Abstract Background MGMT promoter methylation is a well-established biomarker in glioblastoma, its relevance in melanoma brain metastases remains controversial. Recent studies indicate that methylation of MGMT enhancers contributes to MGMT regulation, whereas the role of silencer...