Jizzakh State Pedagogical University

NRF2‐Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities

ABSTRACT Breast cancer remains a significant clinical challenge, particularly in triple‑negative breast cancer (TNBC), in which therapeutic resistance limits treatment efficacy. Ferroptosis, an iron‐dependent form of regulated cell death driven by lipid peroxidation, has emerged...

AN AUTOMATIC SPEECH ASSESSMENT ALGORITHM ADAPTING TO THE PRONUNCIATION CHARACTERISTICS OF CONVICTED PERSONS

A safety-constrained speaker-adaptive algorithm is proposed to separate stable acoustic speaker properties from actual foreign-language pronunciation competence. Two to six unlabeled enrollment utterances estimate baseline F0, timbre, habitual rate, and channel. A small residual...

Decellularized extracellular matrix bioinks through a polymer engineering lens: tissue-source-dependent macromolecular architecture, crosslinking chemistry, rheological behavior, and 3D bioprinting performance

Decellularized extracellular matrix (dECM) bioinks are widely regarded as one of the more compositionally faithful hydrogel platforms for three-dimensional (3D) bioprinting in tissue engineering. However, the field still lacks a unified polymer engineering framework that links ti...

Distributed learning-enabled federated large language model for fake news detection

Fake news detection is the process of detecting misinformative or crafted content spread through social media. Fake news causes social instabilities, increases the data leakage risks, and affects the user's privacy. The prevailing fake news detection models failed to tackle certa...

Explainable Multi-Objective Quantum-Inspired Fuzzy Optimization of Rule Bases for Scalable Load Balancing in Multi-Factor Computing Environments

The rapid growth of cloud and distributed computing systems has increased the complexity of real-time request distribution under dynamic and multi-factor conditions. In such environments, load-balancing decisions must simultaneously consider uncertain and interdependent parameter...

Systematic evidence review on radiosensitizers and the abscopal effects of radiotherapy

BACKGROUND: The abscopal effect, defined as regression of non-irradiated tumors following localized radiotherapy (RT), is increasingly recognized as an immune-mediated phenomenon. Radiosensitizers may enhance this effect by amplifying radiation-induced immunogenicity and systemic...

A genomic resource for a hidden endemic: the complete chloroplast genome of Allium aktauense from Uzbekistan

<ns5:p> <ns5:italic>Allium aktauense</ns5:italic> is a narrow endemic species from the Aktau Range in the Nurotau Mountains, Western Pamir-Alay, where it grows in rocky limestone crevices. Genomic resources for this species have not previously been available, limiting molecular u...