Jinzhou Medical University

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Two-wave modified cardiometabolic index change patterns and incident edentulism in Chinese adults: a longitudinal study from CHARLS

Abstract Objectives Complete tooth loss is a late-stage oral health endpoint that may reflect cumulative oral, systemic, behavioral, and social risk processes. We examined whether two-wave patterns of the modified cardiometabolic index (MCMI) from 2011 to 2015 were associated wit...

Computed tomography-derived body composition parameters as potential predictors of severity and adverse outcomes in viral pneumonia: a retrospective study

Background Following the COVID-19 pandemic, co-infections with multiple respiratory viruses have become increasingly common, complicating the accurate prediction of disease progression and prognosis. This study assessed the use of computed tomography (CT)-derived body composition...

Clinical Relevance of Bile Acid and Bile Acid-Related Therapy in Liver Cirrhosis: A Review

Cirrhosis, the end stage of various chronic liver diseases, is characterized by complex pathophysiologies and poor outcomes. Recently, dysregulation of bile acid metabolism has been increasingly recognized as a key factor in the development and progression of liver cirrhosis and...

Mannose Ameliorates Radiation-Induced Intestinal Injury in Mice via Preventing Mitochondrial Dysfunction

Aims: Radiation-induced intestinal injury (RIII) severely compromises the quality of life in patients undergoing abdominal/pelvic radiotherapy and may necessitate treatment discontinuation. To date, there is no approved agent for the prevention or treatment of RIII. This study ai...

Correlation between high-risk Human Papillomavirus (HPV) viral load and cervical lesions across different subtypes, along with the development of a clinical prediction model

Abstract Objective The study aims to investigate the correlation between the viral loads of HPV16/18 and 16 other high-risk HPV types (designated as non-16/18 group) and the severity of cervical lesions, and to develop a HSIL+ risk prediction model to furnish evidence for pragmat...