Jinzhou Medical University

Psychometric evaluation of the online misinformation susceptibility scale: a translation and validation study among Chinese nurses

With the continued development of the internet, the spread of false and misleading information has become increasingly easy. In the healthcare field, misinformation poses a significant threat to public health, healthcare services, and patient treatment outcomes. Therefore, unders...

GPNMB interacts with SMAD4 to mediate microglial neuroinflammation and induce demyelination in diabetic cognitive dysfunction

Abstract Background Diabetic cognitive dysfunction (DCD) is a prevalent hyperglycaemia-induced central nervous system complication driven by hippocampal neuroinflammation. Glycoprotein non-metastatic melanoma protein B (GPNMB) exerts anti-inflammatory neuroprotection in neurodege...

Experiences and coping strategies among cancer patients with cancer-related cognitive impairment treated with chemotherapy: a mixed-methods systematic review

Cancer-related cognitive impairment (CRCI) is a common, distressing symptom among cancer patients, particularly those undergoing or having completed chemotherapy. Our study seeks to understand the experiences and needs of cancer patients with CRCI, the coping strategies that they...

γ-Aminobutyric Acid Alleviates Discoloration of Or Mutant Cauliflower via BoMYB24-Mediated Transcriptional Regulation of BoLCYB

Abstract Orange (Or) mutant cauliflower is prone to discoloration during storage, which affects its commercial value. γ-Aminobutyric acid (GABA) treatment can effectively delay the discoloration of Or mutant cauliflower during storage; however, its mechanism of action remains unc...

PHPT1/Ocnus negatively regulates the JAK/STAT pathway to control cell survival

The JAK/STAT signaling pathway is a highly conserved regulator essential for animal development. Here, we show that the Drosophila phosphohistidine phosphatase 1, PHPT1/Ocnus, is required for cell survival by regulating JAK/STAT signaling. Knockdown of ocnus ( ocn ) leads to apop...

Lactococcus G423 Improves Lipid Metabolism in Broilers Through the Gut Microbiota and AMPK Signaling Pathway

This study aimed to elucidate the role of Lactococcus G423 in regulating the AMPK (AMP-activated protein kinase) signaling pathway and gut microbiota, and to investigate the mechanisms underlying its potential to improve lipid metabolism in broilers. In this trial, 960 one-day-ol...

Rheum, Scutellaria, and Houttuynia effervescent tablets: a green strategy for controlling Vibrio parahaemolyticus outbreaks in aquaculture

BackgroundThe widespread misuse of antibiotics in aquaculture has led to severe drug resistance, threatening both industry sustainability and food safety. With increasing restrictions on antibiotic use, plant-derived antimicrobials have emerged as eco-friendly alternatives.Purpos...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Machine learning-based prediction model for 2-year tooth loss risk in periodontitis patients: integrating radiographic features and clinical parameters

To develop and internally–externally validate a multidomain machine-learning (ML) model for 2-year tooth loss in periodontitis patients using exclusively baseline predictors, and to quantify the incremental value of radiographic over clinical features. This multicenter retrospect...

Multi-omics analysis reveals extracellular matrix influences glioma progression via remodeling the immune microenvironment

The complex interaction between the extracellular matrix (ECM) and the tumor microenvironment (TME) promotes the immune evasion of glioma cells. This study aims to preliminarily elucidate the impact of ECM on the remodeling of the tumor immune microenvironment through multi-omics...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Two-wave modified cardiometabolic index change patterns and incident edentulism in Chinese adults: a longitudinal study from CHARLS

Abstract Objectives Complete tooth loss is a late-stage oral health endpoint that may reflect cumulative oral, systemic, behavioral, and social risk processes. We examined whether two-wave patterns of the modified cardiometabolic index (MCMI) from 2011 to 2015 were associated wit...

Computed tomography-derived body composition parameters as potential predictors of severity and adverse outcomes in viral pneumonia: a retrospective study

Background Following the COVID-19 pandemic, co-infections with multiple respiratory viruses have become increasingly common, complicating the accurate prediction of disease progression and prognosis. This study assessed the use of computed tomography (CT)-derived body composition...

Clinical Relevance of Bile Acid and Bile Acid-Related Therapy in Liver Cirrhosis: A Review

Cirrhosis, the end stage of various chronic liver diseases, is characterized by complex pathophysiologies and poor outcomes. Recently, dysregulation of bile acid metabolism has been increasingly recognized as a key factor in the development and progression of liver cirrhosis and...

Mannose Ameliorates Radiation-Induced Intestinal Injury in Mice via Preventing Mitochondrial Dysfunction

Aims: Radiation-induced intestinal injury (RIII) severely compromises the quality of life in patients undergoing abdominal/pelvic radiotherapy and may necessitate treatment discontinuation. To date, there is no approved agent for the prevention or treatment of RIII. This study ai...

Correlation between high-risk Human Papillomavirus (HPV) viral load and cervical lesions across different subtypes, along with the development of a clinical prediction model

Abstract Objective The study aims to investigate the correlation between the viral loads of HPV16/18 and 16 other high-risk HPV types (designated as non-16/18 group) and the severity of cervical lesions, and to develop a HSIL+ risk prediction model to furnish evidence for pragmat...