Jinshan Hospital of Fudan University

miR-7a-5p attenuates hypoxic-ischemic encephalopathy by suppressing PARP1-mediated parthanatos

Hypoxic-ischemic encephalopathy (HIE) causes severe neonatal brain injury, with PARP1 hyperactivation implicated in neuronal death. Using a rat HIE model and glutamate-exposed HT22 neurons, we found that miR-7a-5p is significantly downregulated in both peripheral blood and the in...

Cyc.AM-derived FGF9 ignites FGFR1-p38-MAPK-SOX9 axis to reverse acute lung injury

Acute lung injury (ALI) is a life-threatening syndrome driven by alveolar epithelial barrier impairment, with incomplete understanding of alveolar repair mechanisms. This study aimed to identify the cellular and molecular axis mediating alveolar repair and validate its therapeuti...

GSDMB synergizes anti-PD-1 efficacy via Sema7a-mediated CD8+ T Cell infiltration in bladder cancer

Gasdermin B (GSDMB) is highly expressed in bladder cancer (BLCA) and has been implicated in anti-tumor immunity, yet its functional role and underlying mechanisms in enhancing the efficacy of immune checkpoint inhibitors (ICIs) remain unclear. Herein, we demonstrate that GSDMB sy...

A positive feedback loop between HNRNPF and GRHL2 drives NEK8-mediated prostate cancer progression

Prostate cancer (PCa) remains a major cause of cancer-related mortality in men, especially in advanced stages. The role of Heterogeneous Nuclear Ribonucleoprotein F (HNRNPF) in PCa progression is poorly defined. The function and mechanism of HNRNPF were investigated using in vitr...

Integrated postmortem brain transcriptomics identifies a five-gene Alzheimer’s disease-associated signature with a reproducible whole-blood CEBPB correlate

Transcriptomic profiling provides a systems-level view of Alzheimer’s disease (AD), capturing coordinated neuronal, glial, vascular, and immune-related changes. Yet the same breadth that makes transcriptomics informative also complicates interpretation because technical heterogen...

Safety and satisfaction of voluntary medical male circumcision among men who have sex with men in China

PURPOSE: To investigate the safety and satisfaction of circumcision among men who have sex with men (MSM), as voluntary male medical circumcision (VMMC) may be an innovative and acceptable tool for HIV prevention among this population in the future. METHODS: Participants who volu...

Simultaneous broad-spectrum antibacterial and regenerative therapy for diabetic wounds using sonosensitive peptide composite hydrogel

Diabetic wound infections remain highly refractory to treatment due to persistent bacterial colonization, oxidative stress, dysregulated inflammation, vascular insufficiency, and impaired extracellular-matrix remodeling. Current therapeutic strategies remain limited by poor tissu...