Jining Medical University

Deconstruction of Hemp Stalks by Hydrated Deep Eutectic Solvents for Lignocellulosic Nanofibrils Preparation

Abstract The compact hemicellulose and lignin network in hemp stalks restricts fiber nanofibrillation and dispersion stability. Herein, a molecular simulation-guided hydrated deep eutectic solvent (H-DES) strategy was developed for biomass deconstruction and lignocellulosic nanof...

Automated deep learning-based comprehensive assessment of stent in intravascular optical coherence tomography

The process of manually identifying and quantifying coronary stents in intravascular optical coherence tomography (IVOCT) images is time-consuming and subjective. In this study, a deep learning-based target recognition model, SMA-YOLO, was developed for automatic identification a...

Unusual Switch of Cell Death Mode by Docosahexaenoic Acid (DHA) via Enhancing Endoplasmic Reticulum Peroxidation Induced by Lipophilic Iron Complex

Although ferroptosis is a programmed iron-dependent cell death, many lipophilic iron complexes fail to induce ferroptosis through iron overload. The underlying mechanisms remain unclear. Here we found that a typical lipophilic iron complex 8-hydroxyquinoline (8HQ)-Fe(III) (1: 1,...

KARAP Deficiency Alleviates Intestinal Mucosal Barrier Dysfunction by Regulating Mitochondrial Homeostasis in Macrophages

Abstract Background Killer cell activating receptor-associated protein (KARAP) has been implicated in the progression of various inflammatory and immune-mediated diseases, including ulcerative colitis (UC). Although macrophages play a pivotal role in UC pathogenesis, how KARAP re...

Species-Dependent Citrus–Simvastatin Interaction Profiles in an Acute Rat Model: Integrating Drug Disposition, Hepatic Redox, and Complementary Computational Analysis

Abstract Citrus species differ widely in flavonoid chemistry, yet grapefruit has come to represent the genus in citrus–statin interactions. To test whether this translates into species-dependent interaction profiles, six flavonoid-profiled citrus peel extracts (Citrus limon, C. d...

The mediating role of brain structural-functional connectivity coupling in linking paternal education to BMI and depressive scores in young adults

Parental education is associated with body mass index (BMI), mental health, and neurodevelopment in young adults, yet the neurobiological mechanisms remain unclear. This study investigated whether parental education is related to BMI and depressive scores through brain structural...

Extracellular vesicles for next-gen therapeutics and drug delivery

Extracellular vesicles (EVs) are membrane-bound, nano-sized particles released by diverse cell types. They serve as key mediators of intercellular communication by transporting a broad repertoire of proteins, lipids, nucleic acids, and metabolites to recipient cells within a prot...

Emotional and behavioral problems in children of parents with severe mental illness in Wuhan, China: the roles of child maltreatment and exposure to parental victimization

Guided by a developmental-ecological and trauma-informed framework, children of parents with severe mental illness (SMI) may develop emotional and behavioral problems (EBPs) through inherited vulnerability, disrupted caregiving, socioeconomic adversity, stigma, and trauma-related...

Association of low calf circumference and underweight with sarcopenia in older adults with chronic kidney disease: a cross-sectional study

Objectives This community-based, cross-sectional study aimed to evaluate the association of calf circumference and body mass index (BMI) with sarcopenia in older adults with chronic kidney disease (CKD).Methods: Community-dwelling adults aged ≥60 years were enrolled in New Taipei...

Recent Progress in Phosphinamide‐Directed CH Functionalization for the Construction of CX Bonds (XC, N, O)

Organophosphorus compounds are widely used in bioactive molecules, catalysts, and ligands. Recent CH functionalization methods—often guided by directing groups—now enable direct formation of CC, CN, and CO bonds on phosphinamide substrates with improved step efficiency. This...

Distribution and Time Trends of Refractive Errors in Japanese Spectacle Wearers

Purpose: This study aimed to estimate the distribution and temporal trends of refractive errors among spectacle wearers in Japan using a nationwide database of optical chain stores. Methods: Data from 4,525,689 individuals (53.0% women and 47.0% men; age range, 6-35 years) who pu...