Jinhua Central Hospital

Diagnostic Value of FAR, CAR, and PNI in Differentiating Benign From Malignant Endometrial Lesions and Assessing High-Risk Pathological Features

AIM: Benign endometrial lesions and endometrial cancer often overlap in clinical and ultrasonographic features. This study evaluated the ability of the fibrinogen-to-albumin ratio (FAR), C-reactive protein-to-albumin ratio (CAR), and prognostic nutritional index (PNI) to differen...

Identification of independent predictors of successful external cephalic version

This study aimed to determine the success rate of external cephalic version (ECV) and identify independent predictors of successful ECV among women with a term singleton fetus in breech presentation. This retrospective multicenter study included 65 pregnant women who underwent EC...

Development of ferroptosis-related prognostic signature for lung adenocarcinoma and association of fibroblast-enriched RGS4 with favorable prognosis

Lung adenocarcinoma (LUAD) is characterized by high incidence and low survival rate. The molecular network of ferroptosis in lung adenocarcinoma requires further investigation, and this study aims to develop a ferroptosis-related prognostic model and identify the potential biomar...

Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis

Onvansertib (ONV) is a selective inhibitor of polo-like kinase 1 (PLK1) and has promise in treating cancer. However, its potential effects on male reproductive function remain insufficiently characterized. In this study, male mice received clinically relevant doses of ONV by intr...

Involvement of phosphorylated caveolin-1 in the dorsal root ganglion in diabetic neuropathic pain and the interventional effect of electroacupuncture

OBJECTIVE: The aim of the study was to observe the changes in phosphorylated caveolin-1 (p-Cav-1) expression in the dorsal root ganglion (DRG) of rats with diabetic neuropathic pain (DNP) and to explore the interventional effect of electroacupuncture on Cav-1. METHODS: In experim...

Glyoxal induces arterial injury through the inactivation of receptors and signaling pathways

Glyoxal exposure is associated with a spectrum of adverse health outcomes, including arterial injury. While existing evidence confirms that glyoxal targets oxidative stress and the mitogen-activated protein kinase pathway, the precise underlying mechanism of glyoxal-induced arter...

Observed CTIT onset timing is associated with platelet surveillance schedules in a real-world cohort

Chemotherapy-induced thrombocytopenia (CTIT) is detected through platelet testing, so routine-care estimates of onset and recovery may depend on surveillance schedules. We characterized within-cycle timing and assessed whether apparent differences among drug categories persisted...

Exosomes in brain diseases: Mechanisms, advances, and perspectives

The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...

Senescence-related immunosuppressive gene MFAP2 orchestrates stromal-immune crosstalk and immunotherapy resistance in gastric cancer

Abstract Background Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide, with poor prognosis and immune checkpoint inhibitor (ICI) resistance mediated by immune escape. Senescence-related immunosuppressive genes (SRIGs) regulate the tumor microenvironment...