Jinhua Academy of Agricultural Sciences

Identification of independent predictors of successful external cephalic version

This study aimed to determine the success rate of external cephalic version (ECV) and identify independent predictors of successful ECV among women with a term singleton fetus in breech presentation. This retrospective multicenter study included 65 pregnant women who underwent EC...

First Report of Soft Rot on Corydalis yanhusuo Caused by Pectobacterium versatile in China

Corydalis yanhusuo (Yanhusuo) is a traditional Chinese medicinal herb. From March to May 2023 and 2024, a previously unrecorded soft rot was observed in Panan County, Zhejiang Province, China (N29°12', E120°32'), with disease incidence of 10–50% (up to 80% in some fields). Initia...

Development of ferroptosis-related prognostic signature for lung adenocarcinoma and association of fibroblast-enriched RGS4 with favorable prognosis

Lung adenocarcinoma (LUAD) is characterized by high incidence and low survival rate. The molecular network of ferroptosis in lung adenocarcinoma requires further investigation, and this study aims to develop a ferroptosis-related prognostic model and identify the potential biomar...

Intestinal Macrophage-Mediated Exosomal Repackaging Establishes Bioactive Reservoirs for Long-Acting Oral Peptide Therapy

Abstract Oral peptide delivery systems are conventionally engineered to improve intestinal absorption, but they rarely address the progressive and systemic nature of chronic inflammatory disorders such as type-2 diabetes (T2D), which requires both durable glycemic control and imm...

Involvement of phosphorylated caveolin-1 in the dorsal root ganglion in diabetic neuropathic pain and the interventional effect of electroacupuncture

OBJECTIVE: The aim of the study was to observe the changes in phosphorylated caveolin-1 (p-Cav-1) expression in the dorsal root ganglion (DRG) of rats with diabetic neuropathic pain (DNP) and to explore the interventional effect of electroacupuncture on Cav-1. METHODS: In experim...

Glyoxal induces arterial injury through the inactivation of receptors and signaling pathways

Glyoxal exposure is associated with a spectrum of adverse health outcomes, including arterial injury. While existing evidence confirms that glyoxal targets oxidative stress and the mitogen-activated protein kinase pathway, the precise underlying mechanism of glyoxal-induced arter...

Delivery of CAR T Cells in a Magnesium-Functionated Hydrogel Boosts Peritoneal Metastasis Treatment

Abstract Chimeric antigen receptor (CAR) T cells show limited efficacy in solid tumors due to suppressive factors in the tumor microenvironment. In this study, we identified extracellular magnesium (Mg2+) as a pharmacologically modulable regulator of CAR T activity. Mg2+ suppleme...

Airway administered artificial mitochondria-enriched nanovesicles for efficient and selective mitochondria transfer to intervene in pulmonary fibrosis

Mitochondrial transplantation is a promising therapeutic approach involving the transfer of exogenous mitochondria into diseased cells to restore impaired mitochondrial homeostasis. However, its clinical translation is severely limited by the lack of efficient methods for precise...

Senescence-related immunosuppressive gene MFAP2 orchestrates stromal-immune crosstalk and immunotherapy resistance in gastric cancer

Abstract Background Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide, with poor prognosis and immune checkpoint inhibitor (ICI) resistance mediated by immune escape. Senescence-related immunosuppressive genes (SRIGs) regulate the tumor microenvironment...

Diarrhea prevention practices and associated factors among caregivers of under-five children in Jinka town, 2024 community-based cross-sectional study

Diarrhea is one of the world’s major causes of child mortality and morbidity, even though it has preventive solutions. Earlier studies have addressed diarrhea management at home instead of focusing on preventative measures. Hence, this study aimed to assess diarrhea prevention pr...

Bioactive composition and pharmacology of red wine, beer, and Huangjiu (Chinese rice wine): a review

Red wine, beer, and Huangjiu (Chinese rice wine) are widely consumed fermented alcoholic beverages whose compositions and health effects have attracted considerable interest. Current evidence indicates that fermentation endows these beverages with diverse bioactive compounds such...