Jingning County People's Hospital

Prevalence and geographic variation of enteric pathogens among asymptomatic individuals in China: a nationwide, cross-sectional, multiplex molecular survey

The increasing use of multiplex molecular assays has improved the detection of enteric pathogens, but baseline carriage in asymptomatic populations remains poorly characterized, complicating the interpretation of positive test results. We aimed to investigate the prevalence and g...

CSNK2B-associated epilepsy: family report and literature review

Abstract Background CSNK2B mutations are associated with Poirier-Bienvenu neurodevelopmental syndrome (POBINDS), in which epilepsy is a common clinical feature. To describe the epilepsy phenotype of CSNK2B mutations, we reported a family with a novel CSNK2B mutation, added this i...

The marine drug plitidepsin alleviates osteoporosis in estrogen-deficient mice by suppressing ROS-mediated NRF2/HO-1 signaling and osteoclast formation

Abstract Marine-derived compounds represent an important source of innovative therapeutics owing to their structural diversity and broad bioactivity; however, their potential in osteoporosis therapy remains insufficiently explored. This study investigated the effects of plitideps...

An expert-level generalist AI for abdominal CT diagnosis

Artificial intelligence (AI) in radiology aspires to deliver expert-level diagnosis across diverse clinical tasks, yet existing supervised strategies remain limited in scope. We developed RADAR, a generalist vision-language model trained on more than 400,000 contrast-enhanced abd...

Association between USP6NL polymorphisms and Parkinson’s disease in Northern Chinese Han population: a case-control study

The pathogenesis and progression of Parkinson’s disease (PD) are closely associated with impaired membrane trafficking. As a key regulator of membrane trafficking, this study examined the association between two USP6NL polymorphisms (rs61844597 and rs73569171) and PD risk in the...

Association of baseline HALP and PIV/AISI with 2-month sputum culture conversion in newly diagnosed culture-positive pulmonary tuberculosis: a prospective single-center cohort study

Baseline blood composites that summarize nutritional reserve and systemic inflammation may help identify pulmonary tuberculosis patients less likely to achieve early microbiologic response, but prospective evidence remains limited. We conducted a prospective single-center cohort...

Efficacy and safety of combined intravenous and topical tranexamic acid in primary total hip arthroplasty: a meta‑analysis and systematic review of randomized controlled trials

Both intravenous (IV) and topical tranexamic acid (TXA) reduce bleeding in total hip arthroplasty (THA), but the added benefit of combining the two routes and the potential modifying effect of topical dose remain unclear. We performed a systematic review and meta‑analysis of RCTs...

Longitudinal Associations Among Maternal Health Literacy, Psychological Empowerment and Health‐Promoting Behaviours in Rural Pregnant Women: A Cross‐Lagged Panel Study

AIMS: To examine longitudinal associations among maternal health literacy, psychological empowerment and health-promoting behaviours across pregnancy among rural pregnant women. DESIGN: Prospective cohort study. METHODS: Between 1 May 2023 and 15 January 2024, 694 rural pregnant...