Jinan Maternity And Care Hospital

Metabolic Dysregulation and Metabolite-Targeted Interventions in Autism Spectrum Disorder: Mechanisms and Translational Perspectives

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder marked by impaired social communication and restricted repetitive behaviors. Metabolic dysregulation is increasingly recognized as a key intermediate mechanism linking genetic and environmental factors...

An intelligent OCR-LLM prescription review system for inpatient narcotic and psychotropic drugs

This study aimed to construct an intelligent prescription review system for inpatient narcotic and psychotropic drugs based on deep learning-based optical character recognition (OCR) and a local large language model (LLM) and evaluate its review performance and closed-loop manage...

A multiomics-clinical model to predict treatment response in psoriasis

Psoriasis is a chronic inflammatory skin disease with highly variable responses to biologic therapies. Predictive tools to guide personalized treatment remain an unmet clinical need. To develop and validate a multiomics-clinical model for predicting a 75% reduction in the Psorias...

Stakeholder perceptions of an early essential newborn care simulation-based training in western China: a qualitative study

Neonatal mortality remains a global concern, especially in China, where regional disparities persist. Early essential newborn care (EENC) consists of a set of evidence-based and cost-effective interventions, including but not limited to, skin-to-skin contact, neonatal resuscitati...

The deubiquitinase PSMD14 accelerates cervical cancer progression, with thiolutin offering a novel therapeutic approach

Abnormal function of deubiquitination enzymes is implicated in cancer progression. However, the role of the 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) in cervical cancer development and its underlying mechanisms remain poorly understood. In our study, we evaluated t...

Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity

Neutrophils are increasingly recognized as key orchestrators of the immunosuppressive tumor microenvironment, yet their intrinsic plasticity, short lifespan and resistance to genetic manipulation have impeded therapeutic targeting. Here, we report a non-pharmacological, biophysic...

Application of bronchoscopy in children with primary ciliary dyskinesia

To evaluate the value of bronchoscopy in the clinical diagnosis and management of primary ciliary dyskinesia (PCD). A retrospective analysis was conducted on six genetically confirmed PCD children admitted to the Department of Respiratory Intervention at Jinan Children’s Hospital...

Abdominal fat thickness predicts the risk of pregnancy-associated hypertension: A prospective cohort study.

BACKGROUND AND OBJECTIVES: Pregnancy-associated hypertension (PAH) is a prevalent complication during pregnancy. Maternal obesity is a known risk factor for PAH. As nutrition is a key modifiable driver of obesity and metabolic health, this study aimed to evaluate whether early-pr...